Subcutaneous Adipose Tissue Plays A Beneficial Effect On Subclinical Atherosclerosis In Young Survivors Of Acute Lymphocytic Leukemia.

dc.creatorSiviero-Miachon, Adriana Aparecida
dc.creatorSpinola-Castro, Angela Maria
dc.creatorde Martino Lee, Maria Lucia
dc.creatorde Castro Monteiro, Carlos Manoel
dc.creatorde Camargo Carvalho, Antonio Carlos
dc.creatorCalixto, Antonio Ramos
dc.creatorGeloneze, Bruno
dc.creatorGuerra-Junior, Gil
dc.date2015
dc.date2016-05-23T19:41:11Z
dc.date2016-05-23T19:41:11Z
dc.date.accessioned2018-03-29T01:28:41Z
dc.date.available2018-03-29T01:28:41Z
dc.identifierVascular Health And Risk Management. v. 11, p. 479-488, 2015.
dc.identifier1178-2048
dc.identifier10.2147/VHRM.S86883
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/?term=26316772
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/235475
dc.identifier26316772
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1303718
dc.descriptionThe aim of this study was to evaluate the relationship between body composition, metabolic profile, adipokines, and carotid intima-media thickness (cIMT) in young survivors of childhood acute lymphocytic leukemia (ALL). This cross-sectional study compared 55 ALL survivors, of chronological age between 15 years and 24 years, assigned into two groups according to the exposure to cranial radiation therapy (CRT; 25 irradiated and 30 nonirradiated) with 24 leukemia-free controls, and assessed body fat mass (dual-energy X-ray absorptiometry), computed tomography scan-derived abdominal adipose tissue, lipid profile, blood pressure (BP), adipokines, and cIMT by a multiple regression analysis. Treatment with CRT had an effect on all of the variables derived from the computed tomography scan: visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) (P<0.050). In a multiple linear regression model, cIMT positively correlated with exposure to CRT (P=0.029), diastolic BP (P=0.016), and leptin-to-adiponectin ratio (P=0.048), while negatively related to SAT (P=0.007). In young survivors of childhood ALL, CRT modified the distribution of fat and played a critical role in determining cIMT. Leptin-to-adiponectin ratio, a biomarker of abdominal obesity and metabolic syndrome, and diastolic BP also influenced cIMT, a marker of subclinical atherosclerosis. Nonetheless, adiposity-associated vascular disease might be attenuated by SAT. Changes in body fat must be evaluated in this group of patients in the early course of survivorship in order to avoid premature cardiovascular disease associated with atherosclerosis. Yet, further research as regards the possible protective effect of SAT on vascular disease is warranted.
dc.description11
dc.description479-488
dc.languageeng
dc.relationVascular Health And Risk Management
dc.relationVasc Health Risk Manag
dc.rightsaberto
dc.sourcePubMed
dc.subjectAbdominal Fat
dc.subjectAdipokines
dc.subjectAtherosclerosis
dc.subjectEndothelium
dc.subjectMetabolic Syndrome X
dc.subjectPrecursor Cell Lymphoblastic Leukemia–lymphoma/radiotherapy
dc.titleSubcutaneous Adipose Tissue Plays A Beneficial Effect On Subclinical Atherosclerosis In Young Survivors Of Acute Lymphocytic Leukemia.
dc.typeArtículos de revistas


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