Tolerogenic Dendritic Cells On Transplantation: Immunotherapy Based On Second Signal Blockage.

dc.creatorSilva, Priscila de Matos
dc.creatorBier, Julia
dc.creatorPaiatto, Lisiery Negrini
dc.creatorGaldino Albuquerque, Cassia
dc.creatorLopes Souza, Caique
dc.creatorFernandes, Luis Gustavo Romani
dc.creatorTamashiro, Wirla Maria da Silva Cunha
dc.creatorSimioni, Patricia Ucelli
dc.date2015
dc.date2016-05-23T19:40:22Z
dc.date2016-05-23T19:40:22Z
dc.date.accessioned2018-03-29T01:27:56Z
dc.date.available2018-03-29T01:27:56Z
dc.identifierJournal Of Immunology Research. v. 2015, p. 856707, 2015.
dc.identifier2314-7156
dc.identifier10.1155/2015/856707
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/26543876
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/235274
dc.identifier26543876
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1303517
dc.descriptionDendritic cells (DCs), the most important professional antigen-presenting cells (APC), play crucial role in both immunity and tolerance. It is well known that DCs are able to mount immune responses against foreign antigens and simultaneously tolerate self-antigens. Since DCs can be modulated depending on the surrounding microenvironment, they can act as a bridge between innate and adaptive immunity. However, the mechanisms that support this dual role are not entirely clear. Recent studies have shown that DCs can be manipulated ex vivo in order to trigger their tolerogenic profile, what can be a tool to be used in clinical trials aiming the treatment of various diseases and the prevention of transplant rejection. In this sense, the blockage of costimulatory molecules on DC, in the attempt of inhibiting the second signal in the immunological synapse, can be considered as one of the main strategies under development. This review brings an update on current therapies using tolerogenic dendritic cells modulated with costimulatory blockers with the aim of reducing transplant rejection. However, although there are current clinical trials using tolerogenic DC to treat allograft rejection, the actual challenge is to modulate these cells in order to maintain a permanent tolerogenic profile.
dc.description2015
dc.description856707
dc.languageeng
dc.relationJournal Of Immunology Research
dc.relationJ Immunol Res
dc.rightsaberto
dc.sourcePubMed
dc.titleTolerogenic Dendritic Cells On Transplantation: Immunotherapy Based On Second Signal Blockage.
dc.typeArtículos de revistas


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