Espécies reativas de oxigênio e de nitrogênio, antioxidantes e marcadores de dano oxidativo em sangue humano: principais métodos analíticos para sua determinação

Reactive oxygen and nitrogen species, antioxidants and markers of oxidative damage in human blood: main analytical methods for their determination

dc.creatorVasconcelos, Sandra Mary Lima
dc.creatorGoulart, Marília Oliveira Fonseca
dc.creatorMoura, José Benedito de França
dc.creatorManfredini, Vanusa
dc.creatorBenfato, Mara da Silveira
dc.creatorKubota, Lauro Tatsuo
dc.date2007-10-01
dc.date2015-12-03T13:30:46Z
dc.date2015-12-03T13:30:46Z
dc.date.accessioned2018-03-29T01:24:47Z
dc.date.available2018-03-29T01:24:47Z
dc.identifierQuímica Nova. Sociedade Brasileira de Química, v. 30, n. 5, p. 1323-1338, 2007.
dc.identifier0100-4042
dc.identifierS0100-40422007000500046
dc.identifier10.1590/S0100-40422007000500046
dc.identifierhttp://dx.doi.org/10.1590/S0100-40422007000500046
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500046
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/23766
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/202454
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1302687
dc.descriptionWe review here the chemistry of reactive oxygen and nitrogen species, their biological sources and targets; particularly, biomolecules implicated in the redox balance of the human blood, and appraise the analytical methods available for their detection and quantification. Those biomolecules are represented by the enzymatic antioxidant defense machinery, whereas coadjutant reducing protection is provided by several low molecular weight molecules. Biomolecules can be injured by RONS yielding a large repertoire of oxidized products, some of which can be taken as biomarkers of oxidative damage. Their reliable determination is of utmost interest for their potentiality in diagnosis, prevention and treatment of maladies.
dc.description1323
dc.description1338
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languagept
dc.publisherSociedade Brasileira de Química
dc.relationQuímica Nova
dc.rightsaberto
dc.sourceSciELO
dc.subjectbiomarkers of oxidative stress
dc.subjectoxidative and nitrosative stress
dc.subjectantioxidants
dc.titleEspécies reativas de oxigênio e de nitrogênio, antioxidantes e marcadores de dano oxidativo em sangue humano: principais métodos analíticos para sua determinação
dc.titleReactive oxygen and nitrogen species, antioxidants and markers of oxidative damage in human blood: main analytical methods for their determination
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución