Recovery Of The Incretin Effect In Type 2 Diabetic Patients After Biliopancreatic Diversion.

dc.creatorNovaes, Fernanda S
dc.creatorVasques, Ana C J
dc.creatorPareja, José C
dc.creatorKnop, Filip K
dc.creatorTura, Andrea
dc.creatorChaim, Élinton A
dc.creatorGeloneze, Bruno
dc.date2015-Mar
dc.date2015-11-27T13:46:20Z
dc.date2015-11-27T13:46:20Z
dc.date.accessioned2018-03-29T01:23:46Z
dc.date.available2018-03-29T01:23:46Z
dc.identifierThe Journal Of Clinical Endocrinology And Metabolism. , p. jc20144042, 2015-Mar.
dc.identifier1945-7197
dc.identifier10.1210/jc.2014-4042
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25742514
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/202185
dc.identifier25742514
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1302418
dc.descriptionContext: Bariatric surgery often results in remission of the diabetic state in obese patients. Increased incretin effect seems to play an important role in the glycemic improvements after Roux-en-Y gastric bypass, but the impact of biliopancreatic diversion (BPD) remains unexplored. Objective: To elucidate the effect of BPD on the incretin effect and its interplay with beta-cell function and insulin sensitivity (IS) in obese subjects with type 2 diabetes (T2DM). Design, Setting and Patients: Twenty-three women were studied: a control group of 13 lean, normal glucose-tolerant women (lean NGT) studied once and 10 obese patients with T2DM studied before, 1 and 12 months after BPD. Intervention: The ObeseT2DM group underwent BPD. Main Outcome Measures: The change in incretin effect as measured by the isoglycemic intravenous glucose infusion test. Secondary outcomes encompassed IS and beta-cell function. Results: At baseline, the incretin effect was lower in obese T2DM compared to lean NGT (p<0.05). One month after BPD, the incretin effect was not changed, but at 12 months it reached the level of the lean NGT group (p>0.05). IS improved (p<0.05) 1 month after BPD and at 12 months it resembled the levels of the lean NGT group. Insulin secretory rate and beta-cell glucose sensitivity increased after BPD and achieved levels similar to lean NGT group 1 month after BPD and even higher levels at 12 months (p<0.05). Conclusions: BPD has no acute impact on the reduced incretin effect, but 12 months after surgery the incretin effect normalizes alongside normalization of glucose control, IS and beta-cell function.
dc.description
dc.descriptionjc20144042
dc.languageeng
dc.relationThe Journal Of Clinical Endocrinology And Metabolism
dc.relationJ. Clin. Endocrinol. Metab.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.titleRecovery Of The Incretin Effect In Type 2 Diabetic Patients After Biliopancreatic Diversion.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución