[comparative Study Between Fast And Slow Induction Of Propofol Given By Target-controlled Infusion: Expected Propofol Concentration At The Effect Site. Randomized Controlled Trial].

dc.creatorSimoni, Ricardo Francisco
dc.creatorMiziara, Luiz Eduardo de Paula Gomes
dc.creatorEsteves, Luis Otávio
dc.creatorSilva, Diógenes de Oliveira
dc.creatorRibeiro, Cristina Alves
dc.creatorSmith, Mariana Oki
dc.creatorPaula, Leonardo Ferreira de
dc.creatorCangiani, Luis Henrique
dc.date
dc.date2015-11-27T13:46:19Z
dc.date2015-11-27T13:46:19Z
dc.date.accessioned2018-03-29T01:23:45Z
dc.date.available2018-03-29T01:23:45Z
dc.identifierRevista Brasileira De Anestesiologia. v. 65, n. 2, p. 99-103
dc.identifier1806-907X
dc.identifier10.1016/j.bjan.2013.07.015
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25740275
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/202180
dc.identifier25740275
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1302413
dc.descriptionstudies have shown that rate of propofol infusion may influence the predicted propofol concentration at the effect site (Es). The aim of this study was to evaluate the Es predicted by the Marsh pharmacokinetic model (ke0 0.26min(-1)) in loss of consciousness during fast or slow induction. the study included 28 patients randomly divided into two equal groups. In slow induction group (S), target-controlled infusion (TCI) of propofol with plasma, Marsh pharmacokinetic model (ke0 0.26min(-1)) with target concentration (Tc) at 2.0-μg.mL(-1) were administered. When the predicted propofol concentration at the effect site (Es) reached half of Es value, Es was increased to previous Es + 1μg.mL(-1), successively, until loss of consciousness. In rapid induction group (R), patients were induced with TCI of propofol with plasma (6.0μg.ml(-1)) at Es, and waited until loss of consciousness. in rapid induction group, Tc for loss of consciousness was significantly lower compared to slow induction group (1.67±0.76 and 2.50±0.56μg.mL(-1), respectively, p=0.004). the predicted propofol concentration at the effect site for loss of consciousness is different for rapid induction and slow induction, even with the same pharmacokinetic model of propofol and the same balance constant between plasma and effect site.
dc.description65
dc.description99-103
dc.languagepor
dc.relationRevista Brasileira De Anestesiologia
dc.relationRev Bras Anestesiol
dc.rightsfechado
dc.rightsCopyright © 2014 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.
dc.sourcePubMed
dc.subjectAnesthetic Techniques
dc.subjectAnesthetics
dc.subjectAnestésicos
dc.subjectFarmacologia
dc.subjectGeneral
dc.subjectGeral
dc.subjectIntravenous
dc.subjectPharmacology
dc.subjectPropofol
dc.subjectTécnicas Anestésicas
dc.subjectVenosa
dc.subjectVenoso
dc.title[comparative Study Between Fast And Slow Induction Of Propofol Given By Target-controlled Infusion: Expected Propofol Concentration At The Effect Site. Randomized Controlled Trial].
dc.typeArtículos de revistas


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