[effect Of Ropivacaine Combined With Pancuronium On Neuromuscular Transmission And Effectiveness Of Neostigmine And 4-aminopyridine For Blockade Reversal: Experimental Study].

dc.creatorBraga, Angélica de Fátima
dc.creatorCarvalho, Vanessa Henriques
dc.creatorBraga, Franklin Sarmento
dc.creatorPotério, Gloria Maria Braga
dc.creatorSantos, Filipe Nadir Caparica
dc.date
dc.date2015-11-27T13:46:07Z
dc.date2015-11-27T13:46:07Z
dc.date.accessioned2018-03-29T01:23:29Z
dc.date.available2018-03-29T01:23:29Z
dc.identifierRevista Brasileira De Anestesiologia. v. 65, n. 2, p. 136-40
dc.identifier1806-907X
dc.identifier10.1016/j.bjan.2013.10.020
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25666937
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/202110
dc.identifier25666937
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1302343
dc.descriptionThe local anesthetic effects on neuromuscular junction and its influence on blockade produced by nondepolarizing neuromuscular blockers are still under-investigated; however, this interaction has been described in experimental studies and in humans. The aim of this study was to evaluate in vitro the interaction between ropivacaine and pancuronium, the influence on transmission and neuromuscular blockade, and the effectiveness of neostigmine and 4-aminopyridine to reverse the blockade. Rats were divided into groups (n=5) according to the study drug: ropivacaine (5μgmL(-1)); pancuronium (2μg.mL(-1)); ropivacaine+pancuronium. Neostigmine and 4-aminopyridine were used at concentrations of 2μgmL(-1) and 20μgmL(-1), respectively. The effects of ropivacaine on membrane potential and miniature end-plate potential, the amplitude of diaphragm responses before and 60minutes after the addition of ropivacaine (degree of neuromuscular blockade with pancuronium and with the association of pancuronium-ropivacaine), and the effectiveness of neostigmine and 4-aminopyridine on neuromuscular block reversal were evaluated. Ropivacaine did not alter the amplitude of muscle response (the membrane potential), but decreased the frequency and amplitude of the miniature end-plate potential. Pancuronium blockade was potentiated by ropivacaine, and partially and fully reversed by neostigmine and 4-aminopyridine, respectively. Ropivacaine increased the neuromuscular block produced by pancuronium. The complete antagonism with 4-aminopyridine suggests presynaptic action of ropivacaine.
dc.description65
dc.description136-40
dc.languagepor
dc.relationRevista Brasileira De Anestesiologia
dc.relationRev Bras Anestesiol
dc.rightsfechado
dc.rightsCopyright © 2014 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.
dc.sourcePubMed
dc.subjectAnestésicos Locais, Ropivacaina
dc.subjectAnimais, Ratos
dc.subjectAnimals, Rats
dc.subjectBloqueadores Neuromusculares
dc.subjectLocal Anesthetics, Ropivacaine
dc.subjectNeuromuscular Blockers
dc.subjectNondepolarising, Pancuronium
dc.subjectNão Despolarizantes, Pancurônio
dc.title[effect Of Ropivacaine Combined With Pancuronium On Neuromuscular Transmission And Effectiveness Of Neostigmine And 4-aminopyridine For Blockade Reversal: Experimental Study].
dc.typeArtículos de revistas


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