Increased Arterial Stiffness In Resistant Hypertension Is Associated With Inflammatory Biomarkers.

dc.creatorBarbaro, Natália Ruggeri
dc.creatorFontana, Vanessa
dc.creatorModolo, Rodrigo
dc.creatorDe Faria, Ana Paula
dc.creatorSabbatini, Andrea Rodrigues
dc.creatorFonseca, Francisco Helfenstein
dc.creatorAnhê, Gabriel F
dc.creatorMoreno, Heitor
dc.date2015-Feb
dc.date2015-11-27T13:45:58Z
dc.date2015-11-27T13:45:58Z
dc.date.accessioned2018-03-29T01:23:21Z
dc.date.available2018-03-29T01:23:21Z
dc.identifierBlood Pressure. v. 24, n. 1, p. 7-13, 2015-Feb.
dc.identifier1651-1999
dc.identifier10.3109/08037051.2014.940710
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25061978
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/202073
dc.identifier25061978
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1302306
dc.descriptionIncreased levels of inflammatory biomarkers such as interleukin-6 (IL-6), 10 (IL-10), 1β (IL-1β), tumor necrosis factor-α (TNF-α) high-sensitivity C-reactive protein (hs-CRP) are associated with arterial stiffness in hypertension. Indeed, resistant hypertension (RHTN) leads to unfavorable prognosis attributed to poor blood pressure (BP) control and target organ damage. This study evaluated the potential impact of inflammatory biomarkers on arterial stiffness in RHTN. In this cross-sectional study, 32 RHTN, 20 mild hypertensive (HTN) and 20 normotensive (NT) patients were subjected to office BP and arterial stiffness measurements assessed by pulse wave velocity (PWV). Inflammatory biomarkers were measured in plasma samples. PWV was increased in RHTN compared with HTN and NT (p < 0.05). TNF-α levels were significantly higher in RHTN and HTN than NT patients. No differences in IL-6 levels were observed. RHTN patients had a higher frequency of subjects with increased levels of IL-10 and IL-1β compared with HTN and NT patients. Finally, IL-1β was independently associated with PWV (p < 0.001; R(2) = 0.5; β = 0.077). RHTN subjects have higher levels of inflammatory cytokines (TNF-α, IL-1β and IL-10) as well as increased arterial stiffness, and detectable IL-1β levels are associated arterial stiffness. These findings suggest that inflammation plays a possible role in the pathophysiology of RHTN.
dc.description24
dc.description7-13
dc.languageeng
dc.relationBlood Pressure
dc.relationBlood Press.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectArterial Stiffness
dc.subjectInflammatory Cytokines
dc.subjectPulse Wave Velocity
dc.subjectResistant Hypertension
dc.titleIncreased Arterial Stiffness In Resistant Hypertension Is Associated With Inflammatory Biomarkers.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución