Deregulation Of Adipokines Related To Target Organ Damage On Resistant Hypertension.

dc.creatorSabbatini, A R
dc.creatorFaria, A P
dc.creatorBarbaro, N R
dc.creatorGordo, W M
dc.creatorModolo, R G P
dc.creatorPinho, C
dc.creatorFontana, V
dc.creatorMoreno, H
dc.date2014-Jun
dc.date2015-11-27T13:43:40Z
dc.date2015-11-27T13:43:40Z
dc.date.accessioned2018-03-29T01:22:25Z
dc.date.available2018-03-29T01:22:25Z
dc.identifierJournal Of Human Hypertension. v. 28, n. 6, p. 388-92, 2014-Jun.
dc.identifier1476-5527
dc.identifier10.1038/jhh.2013.118
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24284384
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201826
dc.identifier24284384
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1302059
dc.descriptionResistant hypertension (RHTN) includes patients with controlled blood pressure (BP) (CRHTN) and uncontrolled BP (UCRHTN). In fact, RHTN patients are more likely to have target organ damage (TOD), and resistin, leptin and adiponectin may affect BP control in these subjects. We assessed the relationship between adipokines levels and arterial stiffness, left ventricular hypertrophy (LVH) and microalbuminuria (MA). This cross-sectional study included CRHTN (n=51) and UCRHTN (n=38) patients for evaluating body mass index, ambulatory blood pressure monitoring, plasma adiponectin, leptin and resistin concentrations, pulse wave velocity (PWV), MA and echocardiography. Leptin and resistin levels were higher in UCRHTN, whereas adiponectin levels were lower in this same subgroup. Similarly, arterial stiffness, LVH and MA were higher in UCRHTN subgroup. Adiponectin levels negatively correlated with PWV (r=-0.42, P<0.01), and MA (r=-0.48, P<0.01) only in UCRHTN. Leptin was positively correlated with PWV (r=0.37, P=0.02) in UCRHTN subgroup, whereas resistin was not correlated with TOD in both subgroups. Adiponectin is associated with arterial stiffness and renal injury in UCRHTN patients, whereas leptin is associated with arterial stiffness in the same subgroup. Taken together, our results showed that those adipokines may contribute to vascular and renal damage in UCRHTN patients.
dc.description28
dc.description388-92
dc.languageeng
dc.relationJournal Of Human Hypertension
dc.relationJ Hum Hypertens
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdipokines
dc.subjectAdiponectin
dc.subjectAged
dc.subjectAlbuminuria
dc.subjectAntihypertensive Agents
dc.subjectBiological Markers
dc.subjectBlood Chemical Analysis
dc.subjectBlood Pressure Monitoring, Ambulatory
dc.subjectBody Mass Index
dc.subjectBrazil
dc.subjectCross-sectional Studies
dc.subjectDisease Progression
dc.subjectDrug Resistance
dc.subjectEchocardiography, Doppler
dc.subjectFemale
dc.subjectHumans
dc.subjectHypertension
dc.subjectHypertrophy, Left Ventricular
dc.subjectLeptin
dc.subjectLinear Models
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMultivariate Analysis
dc.subjectPrognosis
dc.subjectPulse Wave Analysis
dc.subjectResistin
dc.subjectStatistics, Nonparametric
dc.subjectVascular Resistance
dc.subjectVascular Stiffness
dc.titleDeregulation Of Adipokines Related To Target Organ Damage On Resistant Hypertension.
dc.typeArtículos de revistas


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