Human Herpesvirus-6 And Cytomegalovirus Dna In Liver Donor Biopsies And Their Correlation With Hla Matches And Acute Cellular Rejection.

dc.creatorGuardia, Ana Carolina
dc.creatorStucchi, Raquel Silveira Bello
dc.creatorMilan, Arlete
dc.creatorCosta, Sandra Cecília Botelho
dc.creatorBoin, Ilka de Fátima Santana Ferreira
dc.date
dc.date2015-11-27T13:43:38Z
dc.date2015-11-27T13:43:38Z
dc.date.accessioned2018-03-29T01:22:22Z
dc.date.available2018-03-29T01:22:22Z
dc.identifierThe Brazilian Journal Of Infectious Diseases : An Official Publication Of The Brazilian Society Of Infectious Diseases. v. 18, n. 2, p. 220-4
dc.identifier1678-4391
dc.identifier10.1016/j.bjid.2013.07.007
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24275367
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201815
dc.identifier24275367
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1302048
dc.descriptionHerpesvirus reactivation is common after liver transplantation. Analyze the presence of cytomegalovirus (HCMV) and human herpesvirus-6 (HHV-6) DNA in liver donor biopsies, seeking to better understand issues involving human donor leukocyte antigens (HLA)-A, B and DR, as well as correlations with acute cellular rejection. Fifty-nine liver transplantation patients were investigated for the presence of HCMV and HHV-6 DNA in liver donor biopsies, using the Nested-PCR technique. The clinical donor information and HLA matches were obtained from the São Paulo State Transplant System. The recipients' records regarding acute cellular rejection were studied. Seven (11.8%) biopsies were positive for HCMV DNA and 29 (49%) were positive for HHV-6 DNA. In 14 donors with HLA-DR 15 nine had HHV-6 DNA positive liver biopsy with a tendency for significant association (p=0.09), 22 recipients developed acute cellular rejection and 9/22 were positive for HLA-DR 15 (p=0.03; χ(2)=4.51), which was statistically significant in univariate analysis and showed a tendency after multivariate analysis (p=0.08). HHV-6 DNA was prevalent in liver donors studied as well as HLA-DR 15. These findings suggest that patients with HLA-DR 15 in liver donor biopsies develop more rejection after liver transplantation.
dc.description18
dc.description220-4
dc.languageeng
dc.relationThe Brazilian Journal Of Infectious Diseases : An Official Publication Of The Brazilian Society Of Infectious Diseases
dc.relationBraz J Infect Dis
dc.rightsfechado
dc.rightsCopyright © 2013 Elsevier Editora Ltda. All rights reserved.
dc.sourcePubMed
dc.subjectAcute Disease
dc.subjectAdult
dc.subjectBiopsy
dc.subjectCohort Studies
dc.subjectCytomegalovirus
dc.subjectCytomegalovirus Infections
dc.subjectDna, Viral
dc.subjectFemale
dc.subjectGraft Rejection
dc.subjectHla-dr Antigens
dc.subjectHerpesvirus 6, Human
dc.subjectHumans
dc.subjectLiver
dc.subjectLiver Transplantation
dc.subjectMale
dc.subjectPolymerase Chain Reaction
dc.subjectProspective Studies
dc.subjectRoseolovirus Infections
dc.subjectVirus Activation
dc.subjectCytomegalovirus
dc.subjectHuman Herpesvirus 6
dc.subjectLiver Donor Biopsies
dc.subjectLiver Transplantation
dc.titleHuman Herpesvirus-6 And Cytomegalovirus Dna In Liver Donor Biopsies And Their Correlation With Hla Matches And Acute Cellular Rejection.
dc.typeArtículos de revistas


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