Anxiety-like Effects Of Meta-chlorophenylpiperazine In Paradoxically Sleep-deprived Mice.

dc.creatorPolesel, Daniel Ninello
dc.creatorFukushiro, Daniela Fukue
dc.creatorAndersen, Monica Levy
dc.creatorNozoe, Karen Tieme
dc.creatorMári-Kawamoto, Elisa
dc.creatorSaito, Luís Paulo
dc.creatorCarvalho, Fábio Ramos Souza
dc.creatorAlvarenga, Tathiana Aparecida
dc.creatorFreitas, Denise
dc.creatorTufik, Sergio
dc.creatorFrussa-Filho, Roberto
dc.creatorLanaro, Rafael
dc.creatorCosta, José Luiz
dc.creatorTavares, Marina Franco Maggi
dc.date2014-Mar
dc.date2015-11-27T13:43:34Z
dc.date2015-11-27T13:43:34Z
dc.date.accessioned2018-03-29T01:22:17Z
dc.date.available2018-03-29T01:22:17Z
dc.identifierProgress In Neuro-psychopharmacology & Biological Psychiatry. v. 49, p. 70-7, 2014-Mar.
dc.identifier1878-4216
dc.identifier10.1016/j.pnpbp.2013.11.007
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24269663
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201793
dc.identifier24269663
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1302026
dc.descriptionChlorophenylpiperazines (CPP) are psychotropic drugs used in nightclub parties and are frequently used in a state of sleep deprivation, a condition which can potentiate the effects of psychoactive drugs. This study aimed to investigate the effects of sleep deprivation and sleep rebound (RB) on anxiety-like measures in mCPP-treated mice using the open field test. We first optimized our procedure by performing dose-effect curves and examining different pretreatment times in naïve male Swiss mice. Subsequently, a separate cohort of mice underwent paradoxical sleep deprivation (PSD) for 24 or 48h. In the last experiment, immediately after the 24h-PSD period, mice received an injection of saline or mCPP, but their general activity was quantified in the open field only after the RB period (24 or 48h). The dose of 5mgmL(-1) of mCPP was the most effective at decreasing rearing behavior, with peak effects 15min after injection. PSD decreased locomotion and rearing behaviors, thereby inhibiting a further impairment induced by mCPP. Plasma concentrations of mCPP were significantly higher in PSD 48h animals compared to the non-PSD control group. Twenty-four hours of RB combined with mCPP administration produced a slight reduction in locomotion. Our results show that mCPP was able to significantly change the behavior of naïve, PSD, and RB mice. When combined with sleep deprivation, there was a higher availability of drug in plasma levels. Taken together, our results suggest that sleep loss can enhance the behavioral effects of the potent psychoactive drug, mCPP, even after a period of rebound sleep.
dc.description49
dc.description70-7
dc.languageeng
dc.relationProgress In Neuro-psychopharmacology & Biological Psychiatry
dc.relationProg. Neuropsychopharmacol. Biol. Psychiatry
dc.rightsfechado
dc.rightsCrown Copyright © 2013. Published by Elsevier Inc. All rights reserved.
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAnxiety
dc.subjectBehavior, Animal
dc.subjectDesigner Drugs
dc.subjectDose-response Relationship, Drug
dc.subjectMale
dc.subjectMice
dc.subjectPiperazines
dc.subjectSleep Deprivation
dc.subjectCpp
dc.subjectCtrl
dc.subjectChlorophenylpiperazines
dc.subjectControl
dc.subjectDesigner Drugs
dc.subjectIntraperitoneal
dc.subjectLc-ms/ms
dc.subjectLiquid Chromatography-tandem Mass Spectrometry
dc.subjectMdma
dc.subjectMtbe
dc.subjectMeta-chlorophenylpiperazine
dc.subjectMethyl Tert-butyl Ether
dc.subjectMethylenedioxymethamphetamine
dc.subjectOf
dc.subjectOpen Field
dc.subjectOrto-chlorophenylpiperazine
dc.subjectPsd
dc.subjectParadoxical Sleep Deprivation
dc.subjectQc
dc.subjectQuality Control
dc.subjectRb
dc.subjectSrm
dc.subjectSelected Reaction Monitoring
dc.subjectSleep Deprivation
dc.subjectSleep Rebound
dc.subjectIp
dc.subjectMcpp
dc.subjectOcpp
dc.titleAnxiety-like Effects Of Meta-chlorophenylpiperazine In Paradoxically Sleep-deprived Mice.
dc.typeArtículos de revistas


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