Whole Cortical And Default Mode Network Mean Functional Connectivity As Potential Biomarkers For Mild Alzheimer's Disease.

dc.creatorBalthazar, Marcio Luiz Figueredo
dc.creatorde Campos, Brunno Machado
dc.creatorFranco, Alexandre Rosa
dc.creatorDamasceno, Benito Pereira
dc.creatorCendes, Fernando
dc.date2014-Jan
dc.date2015-11-27T13:43:30Z
dc.date2015-11-27T13:43:30Z
dc.date.accessioned2018-03-29T01:22:12Z
dc.date.available2018-03-29T01:22:12Z
dc.identifierPsychiatry Research. v. 221, n. 1, p. 37-42, 2014-Jan.
dc.identifier1872-7123
dc.identifier10.1016/j.pscychresns.2013.10.010
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24268581
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201771
dc.identifier24268581
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1302004
dc.descriptionThe search for an Alzheimer's disease (AD) biomarker is one of the most relevant contemporary research topics due to the high prevalence and social costs of the disease. Functional connectivity (FC) of the default mode network (DMN) is a plausible candidate for such a biomarker. We evaluated 22 patients with mild AD and 26 age- and gender-matched healthy controls. All subjects underwent resting functional magnetic resonance imaging (fMRI) in a 3.0 T scanner. To identify the DMN, seed-based FC of the posterior cingulate was calculated. We also measured the sensitivity/specificity of the method, and verified a correlation with cognitive performance. We found a significant difference between patients with mild AD and controls in average z-scores: DMN, whole cortical positive (WCP) and absolute values. DMN individual values showed a sensitivity of 77.3% and specificity of 70%. DMN and WCP values were correlated to global cognition and episodic memory performance. We showed that individual measures of DMN connectivity could be considered a promising method to differentiate AD, even at an early phase, from normal aging. Further studies with larger numbers of participants, as well as validation of normal values, are needed for more definitive conclusions.
dc.description221
dc.description37-42
dc.languageeng
dc.relationPsychiatry Research
dc.relationPsychiatry Res
dc.rightsfechado
dc.rights© 2013 Published by Elsevier Ireland Ltd.
dc.sourcePubMed
dc.subjectAged
dc.subjectAlzheimer Disease
dc.subjectBiological Markers
dc.subjectBrain
dc.subjectBrain Mapping
dc.subjectCase-control Studies
dc.subjectCognition Disorders
dc.subjectFemale
dc.subjectHumans
dc.subjectImage Processing, Computer-assisted
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectMemory, Episodic
dc.subjectMiddle Aged
dc.subjectSensitivity And Specificity
dc.subjectSeverity Of Illness Index
dc.subjectBiomarker
dc.subjectDefault Mode Network
dc.subjectDementia
dc.subjectResting State Fmri
dc.titleWhole Cortical And Default Mode Network Mean Functional Connectivity As Potential Biomarkers For Mild Alzheimer's Disease.
dc.typeArtículos de revistas


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