Crosstalk Between Kinases, Phosphatases And Mirnas In Cancer.

dc.creatorAbrantes, Júlia L F
dc.creatorTornatore, Thaís F
dc.creatorPelizzaro-Rocha, Karin J
dc.creatorde Jesus, Marcelo B
dc.creatorCartaxo, Rodrigo T
dc.creatorMilani, Renato
dc.creatorFerreira-Halder, Carmen V
dc.date2014-Dec
dc.date2015-11-27T13:43:23Z
dc.date2015-11-27T13:43:23Z
dc.date.accessioned2018-03-29T01:22:03Z
dc.date.available2018-03-29T01:22:03Z
dc.identifierBiochimie. v. 107 Pt B, p. 167-87, 2014-Dec.
dc.identifier1638-6183
dc.identifier10.1016/j.biochi.2014.09.011
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25230087
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201729
dc.identifier25230087
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301962
dc.descriptionReversible phosphorylation of proteins, performed by kinases and phosphatases, is the major post translational protein modification in eukaryotic cells. This intracellular event represents a critical regulatory mechanism of several signaling pathways and can be related to a vast array of diseases, including cancer. Cancer research has produced increasing evidence that kinase and phosphatase activity can be compromised by mutations and also by miRNA silencing, performed by small non-coding and endogenously produced RNA molecules that lead to translational repression. miRNAs are believed to target about one-third of human mRNAs while a single miRNA may target about 200 transcripts simultaneously. Regulation of the phosphorylation balance by miRNAs has been a topic of intense research over the last years, spanning topics going as far as cancer aggressiveness and chemotherapy resistance. By addressing recent studies that have shown miRNA expression patterns as phenotypic signatures of cancers and how miRNA influence cellular processes such as apoptosis, cell cycle control, angiogenesis, inflammation and DNA repair, we discuss how kinases, phosphatases and miRNAs cooperatively act in cancer biology.
dc.description107 Pt B
dc.description167-87
dc.languageeng
dc.relationBiochimie
dc.relationBiochimie
dc.rightsfechado
dc.rightsCopyright © 2014 Elsevier B.V. and Société française de biochimie et biologie Moléculaire (SFBBM). All rights reserved.
dc.sourcePubMed
dc.subjectCancer Aggressiveness
dc.subjectCell Signaling
dc.subjectChemotherapy Resistance
dc.subjectProtein Tyrosine Kinases
dc.subjectProtein Tyrosine Phosphatases
dc.subjectMirna
dc.titleCrosstalk Between Kinases, Phosphatases And Mirnas In Cancer.
dc.typeArtículos de revistas


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