Histologic Correlation Of Expression Of Ki-67 In Squamous Cell Carcinoma Of The Glottis According To The Degree Of Cell Differentiation.

dc.creatorBonhin, Rodrigo Gonzalez
dc.creatorCarvalho, Guilherme Machado de
dc.creatorGuimarães, Alexandre Caixeta
dc.creatorChone, Carlos Takahiro
dc.creatorCrespo, Agrício Nubiato
dc.creatorAltemani, Albina Messias de Almeida Milani
dc.creatorAmstalden, Eliane M I
dc.date
dc.date2015-11-27T13:43:16Z
dc.date2015-11-27T13:43:16Z
dc.date.accessioned2018-03-29T01:21:51Z
dc.date.available2018-03-29T01:21:51Z
dc.identifierBrazilian Journal Of Otorhinolaryngology. v. 80, n. 4, p. 290-5
dc.identifier1808-8686
dc.identifier10.1016/j.bjorl.2014.05.016
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25183178
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201682
dc.identifier25183178
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301915
dc.descriptionSquamous cell carcinoma is the most common neoplasm of the larynx and glottis, and its prognosis depends on the size of the lesion, level of local invasion, cervical lymphatic spread, and presence of distant metastases. Ki-67 (MKI67) is a protein present in the core, whose function is related to cell proliferation. To evaluate the expression of marker Ki-67 in squamous cell carcinoma of the larynx and glottis and its correlation to pathological findings. Experimental study with immunohistochemistry analysis of Ki-67, calculating the percentage of the cell proliferation index in glottic squamous cell carcinomas. Sixteen cases were analyzed, with six well-differentiated and 10 poorly/moderately differentiated tumors. There was a correlation between cell proliferation index and degree of cell differentiation, with higher proliferation in poorly/moderately differentiated tumors. The cell proliferation index, as measured by Ki-67, may be useful in the characterization of histological degree in glottic squamous cell tumors.
dc.description80
dc.description290-5
dc.languageeng
dc.relationBrazilian Journal Of Otorhinolaryngology
dc.relationBraz J Otorhinolaryngol
dc.rightsaberto
dc.rightsCopyright © 2014 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.
dc.sourcePubMed
dc.subjectAdult
dc.subjectAged
dc.subjectCarcinoma, Squamous Cell
dc.subjectCell Differentiation
dc.subjectCell Proliferation
dc.subjectCohort Studies
dc.subjectCross-sectional Studies
dc.subjectFemale
dc.subjectGlottis
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectKi-67 Antigen
dc.subjectLaryngeal Neoplasms
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasm Staging
dc.subjectPredictive Value Of Tests
dc.subjectPrognosis
dc.subjectTumor Markers, Biological
dc.subjectBiological Markers
dc.subjectCarcinoma De Células Escamosas
dc.subjectCarcinoma, Squamous Cell
dc.subjectCell Proliferation
dc.subjectGlote
dc.subjectGlottis
dc.subjectHead And Neck Neoplasms
dc.subjectMarcadores Biológicos
dc.subjectNeoplasias De Cabeça E Pescoço
dc.subjectProliferação De Células
dc.titleHistologic Correlation Of Expression Of Ki-67 In Squamous Cell Carcinoma Of The Glottis According To The Degree Of Cell Differentiation.
dc.typeArtículos de revistas


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