Rapidly Switching Multidirectional Defibrillation: Reversal Of Ventricular Fibrillation With Lower Energy Shocks.

dc.creatorViana, Marcelo A
dc.creatorBassani, Rosana A
dc.creatorPetrucci, Orlando
dc.creatorMarques, Denilson A
dc.creatorBassani, José Wilson M
dc.date2014-Dec
dc.date2015-11-27T13:43:15Z
dc.date2015-11-27T13:43:15Z
dc.date.accessioned2018-03-29T01:21:50Z
dc.date.available2018-03-29T01:21:50Z
dc.identifierThe Journal Of Thoracic And Cardiovascular Surgery. v. 148, n. 6, p. 3213-8, 2014-Dec.
dc.identifier1097-685X
dc.identifier10.1016/j.jtcvs.2014.07.035
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25173125
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201675
dc.identifier25173125
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301908
dc.descriptionCardiac arrest after open surgery has an incidence of approximately 3%, of which more than 50% of the cases are due to ventricular fibrillation. Electrical defibrillation is the most effective therapy for terminating cardiac arrhythmias associated with unstable hemodynamics. The excitation threshold of myocardial microstructures is lower when external electrical fields are applied in the longitudinal direction with respect to the major axis of cells. However, in the heart, cell bundles are disposed in several directions. Improved myocardial excitation and defibrillation have been achieved by applying shocks in multiple directions via intracardiac leads, but the results are controversial when the electrodes are not located within the cardiac chambers. This study was designed to test whether rapidly switching shock delivery in 3 directions could increase the efficiency of direct defibrillation. A multidirectional defibrillator and paddles bearing 3 electrodes each were developed and used in vivo for the reversal of electrically induced ventricular fibrillation in an anesthetized open-chest swine model. Direct defibrillation was performed by unidirectional and multidirectional shocks applied in an alternating fashion. Survival analysis was used to estimate the relationship between the probability of defibrillation and the shock energy. Compared with shock delivery in a single direction in the same animal population, the shock energy required for multidirectional defibrillation was 20% to 30% lower (P < .05) within a wide range of success probabilities. Rapidly switching multidirectional shock delivery required lower shock energy for ventricular fibrillation termination and may be a safer alternative for restoring cardiac sinus rhythm.
dc.description148
dc.description3213-8
dc.languageeng
dc.relationThe Journal Of Thoracic And Cardiovascular Surgery
dc.relationJ. Thorac. Cardiovasc. Surg.
dc.rightsfechado
dc.rightsCopyright © 2014 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.
dc.sourcePubMed
dc.subjectAnimals
dc.subjectDefibrillators
dc.subjectDisease Models, Animal
dc.subjectElectric Countershock
dc.subjectEquipment Design
dc.subjectFemale
dc.subjectHemodynamics
dc.subjectTime Factors
dc.subjectVentricular Fibrillation
dc.titleRapidly Switching Multidirectional Defibrillation: Reversal Of Ventricular Fibrillation With Lower Energy Shocks.
dc.typeArtículos de revistas


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