Artículos de revistas
Stereoselective Synthesis Of Aryl Cyclopentene Scaffolds By Heck-matsuda Desymmetrization Of 3-cyclopentenol.
Registro en:
Chemistry (weinheim An Der Bergstrasse, Germany). v. 20, n. 41, p. 13117-21, 2014-Oct.
1521-3765
10.1002/chem.201404159
25155478
Autor
Angnes, Ricardo A
Oliveira, Juliana M
Oliveira, Caio C
Martins, Nelson C
Correia, Carlos Roque D
Institución
Resumen
A new enantioselective Heck-Matsuda desymmetrization reaction was accomplished by using 3-cyclopentenol to produce chiral five-membered 4-aryl cyclopentenol scaffolds in good yields and high ee's, together with some 3-aryl-cyclopentanones as minor products. Mechanistically, the hydroxyl group of 3-cyclopentenol acts as a directing group and is responsible for the cis- arrangement in the formation of the 4-aryl-cyclopentenols. 20 13117-21