Effect Of Aloe Vera Application On The Content And Molecular Arrangement Of Glycosaminoglycans During Calcaneal Tendon Healing.

dc.creatorAro, Andrea Aparecida de
dc.creatorEsquisatto, Marcelo Augusto Marretto
dc.creatorNishan, Umar
dc.creatorPerez, Mylena Oliveira
dc.creatorRodrigues, Rodney Alexandre Ferreira
dc.creatorFoglio, Mary Ann
dc.creatorCarvalho, João Ernesto de
dc.creatorGomes, Laurecir
dc.creatorVidal, Benedicto De Campos
dc.creatorPimentel, Edson Rosa
dc.date2014-Dec
dc.date2015-11-27T13:43:11Z
dc.date2015-11-27T13:43:11Z
dc.date.accessioned2018-03-29T01:21:43Z
dc.date.available2018-03-29T01:21:43Z
dc.identifierMicroscopy Research And Technique. v. 77, n. 12, p. 964-73, 2014-Dec.
dc.identifier1097-0029
dc.identifier10.1002/jemt.22422
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25147000
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201648
dc.identifier25147000
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301881
dc.descriptionAlthough several treatments for tendon lesions have been proposed, successful tendon repair remains a great challenge for orthopedics, especially considering the high incidence of re-rupture of injured tendons. Our aim was to evaluate the pharmacological potential of Aloe vera on the content and arrangement of glycosaminoglycans (GAGs) during tendon healing, which was based on the effectiveness of A. vera on collagen organization previously observed by our group. In rats, a partial calcaneal tendon transection was performed with subsequent topical A. vera application at the injury site. The tendons were treated with A. vera ointment for 7 days and excised on the 7(th) , 14(th) , or 21(st) day post-surgery. Control rats received ointment without A. vera. A higher content of GAGs and a lower amount of dermatan sulfate were detected in the A. vera-treated group on the 14(th) day compared with the control. Also at 14 days post-surgery, a lower dichroic ratio in toluidine blue stained sections was observed in A. vera-treated tendons compared with the control. No differences were observed in the chondroitin-6-sulfate and TGF-β1 levels between the groups, and higher amount of non-collagenous proteins was detected in the A. vera-treated group on the 21(st) day, compared with the control group. No differences were observed in the number of fibroblasts, inflammatory cells and blood vessels between the groups. The application of A. vera during tendon healing modified the arrangement of GAGs and increased the content of GAGs and non-collagenous proteins.
dc.description77
dc.description964-73
dc.languageeng
dc.relationMicroscopy Research And Technique
dc.relationMicrosc. Res. Tech.
dc.rightsfechado
dc.rights© 2014 Wiley Periodicals, Inc.
dc.sourcePubMed
dc.subjectDichroic Ratio
dc.subjectInjury
dc.subjectNon-collagenous Proteins
dc.subjectOintment
dc.subjectProteoglycans
dc.titleEffect Of Aloe Vera Application On The Content And Molecular Arrangement Of Glycosaminoglycans During Calcaneal Tendon Healing.
dc.typeArtículos de revistas


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