Cognitive And Behavioral Heterogeneity In Genetic Syndromes.

dc.creatorPegoraro, Luiz F L
dc.creatorSteiner, Carlos E
dc.creatorCeleri, Eloisa H R V
dc.creatorBanzato, Claudio E M
dc.creatorDalgalarrondo, Paulo
dc.date
dc.date2015-11-27T13:42:58Z
dc.date2015-11-27T13:42:58Z
dc.date.accessioned2018-03-29T01:21:26Z
dc.date.available2018-03-29T01:21:26Z
dc.identifierJornal De Pediatria. v. 90, n. 2, p. 155-60
dc.identifier1678-4782
dc.identifier10.1016/j.jped.2013.06.010
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24184301
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201573
dc.identifier24184301
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301806
dc.descriptionthis study aimed to investigate the cognitive and behavioral profiles, as well as the psychiatric symptoms and disorders in children with three different genetic syndromes with similar sociocultural and socioeconomic backgrounds. thirty-four children aged 6 to 16 years, with Williams-Beuren syndrome (n=10), Prader-Willi syndrome (n=11), and Fragile X syndrome (n=13) from the outpatient clinics of Child Psychiatry and Medical Genetics Department were cognitively assessed through the Wechsler Intelligence Scale for Children (WISC-III). Afterwards, a full-scale intelligence quotient (IQ), verbal IQ, performance IQ, standard subtest scores, as well as frequency of psychiatric symptoms and disorders were compared among the three syndromes. significant differences were found among the syndromes concerning verbal IQ and verbal and performance subtests. Post-hoc analysis demonstrated that vocabulary and comprehension subtest scores were significantly higher in Williams-Beuren syndrome in comparison with Prader-Willi and Fragile X syndromes, and block design and object assembly scores were significantly higher in Prader-Willi syndrome compared with Williams-Beuren and Fragile X syndromes. Additionally, there were significant differences between the syndromes concerning behavioral features and psychiatric symptoms. The Prader-Willi syndrome group presented a higher frequency of hyperphagia and self-injurious behaviors. The Fragile X syndrome group showed a higher frequency of social interaction deficits; such difference nearly reached statistical significance. the three genetic syndromes exhibited distinctive cognitive, behavioral, and psychiatric patterns.
dc.description90
dc.description155-60
dc.languageeng
dc.relationJornal De Pediatria
dc.relationJ Pediatr (Rio J)
dc.rightsaberto
dc.rightsCopyright © 2013 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectChild
dc.subjectCognition
dc.subjectCognition Disorders
dc.subjectCross-sectional Studies
dc.subjectEducational Status
dc.subjectFemale
dc.subjectFragile X Syndrome
dc.subjectHumans
dc.subjectIncome
dc.subjectIntellectual Disability
dc.subjectMale
dc.subjectMental Disorders
dc.subjectPrader-willi Syndrome
dc.subjectWechsler Scales
dc.subjectWilliams Syndrome
dc.subjectBehavior
dc.subjectCognition
dc.subjectCognição
dc.subjectComportamento
dc.subjectFragile X Syndrome
dc.subjectPrader-willi Syndrome
dc.subjectSíndrome De Prader-willi
dc.subjectSíndrome De Williams-beuren
dc.subjectSíndrome Do X-frágil
dc.subjectWilliams-beuren Syndrome
dc.titleCognitive And Behavioral Heterogeneity In Genetic Syndromes.
dc.typeArtículos de revistas


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