Ghost Cells In Pilomatrixoma, Craniopharyngioma, And Calcifying Cystic Odontogenic Tumor: Histological, Immunohistochemical, And Ultrastructural Study.

dc.creatorRumayor, Alicia
dc.creatorCarlos, Román
dc.creatorMolina Kirsch, Hernán
dc.creatorde Andrade, Bruno A Benevenuto
dc.creatorRomañach, Mario J
dc.creatorde Almeida, Oslei Paes
dc.date2014-Jul
dc.date2015-11-27T13:42:56Z
dc.date2015-11-27T13:42:56Z
dc.date.accessioned2018-03-29T01:21:24Z
dc.date.available2018-03-29T01:21:24Z
dc.identifierJournal Of Oral Pathology & Medicine : Official Publication Of The International Association Of Oral Pathologists And The American Academy Of Oral Pathology. , 2014-Jul.
dc.identifier1600-0714
dc.identifier10.1111/jop.12234
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/25047924
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201564
dc.identifier25047924
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301797
dc.descriptionPilomatrixoma, craniopharyngioma, and calcifying cystic odontogenic tumor are the main entities presenting ghost cells as an important histological feature, in spite their quite different clinical presentation; it seems that they share a common pathway in the formation of these cells. The aim of this study is to examine and compare the characteristics of ghost and other cells that form these lesions. Forty-three cases including 21 pilomatrixomas, 14 craniopharyngiomas, and eight calcifying cystic odontogenic tumors were evaluated by immunohistochemistry for cytokeratins, CD138, β-catenin, D2-40, Glut-1, FAS, CD10 and also by scanning electron microscopy. The CKs, CD138, β-catenin, Glut-1, FAS, and CD10 were more often expressed by transitional cells of craniopharyngioma and calcifying cystic odontogenic tumor, compared with pilomatrixoma. Basaloid cells of pilomatrixoma showed strong positivity for CD138 and CD10. Differences on expression pattern were identified in transitional and basal cells, as ghost cells were negative for most antibodies used, except by low expression for cytokeratins. By scanning electron microscopy, the morphology of ghost cells were similar in their fibrillar cytoplasm, but their pattern varied from sheets in pilomatrixoma to small clusters in craniopharyngioma and calcifying cystic odontogenic tumor. Mechanisms involved in formation of ghost cells are unknown, but probably they follow different pathways as protein expression in the basal/transitional cells was not uniform in the three tumors studied.
dc.description
dc.description
dc.languageeng
dc.relationJournal Of Oral Pathology & Medicine : Official Publication Of The International Association Of Oral Pathologists And The American Academy Of Oral Pathology
dc.relationJ. Oral Pathol. Med.
dc.rightsfechado
dc.rights© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
dc.sourcePubMed
dc.subjectCalcifying Cystic Odontogenic Tumor
dc.subjectCraniopharyngioma
dc.subjectGhost Cells
dc.subjectImmunohistochemistry
dc.subjectPilomatrixoma
dc.titleGhost Cells In Pilomatrixoma, Craniopharyngioma, And Calcifying Cystic Odontogenic Tumor: Histological, Immunohistochemical, And Ultrastructural Study.
dc.typeArtículos de revistas


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