The Applicability Of Ordered Mesoporous Sba-15 And Its Hydrophobic Glutaraldehyde-bridge Derivative To Improve Ibuprofen-loading In Releasing System.

dc.creatorRehman, Fozia
dc.creatorVolpe, Pedro L O
dc.creatorAiroldi, Claudio
dc.date2014-Jul
dc.date2015-11-27T13:42:31Z
dc.date2015-11-27T13:42:31Z
dc.date.accessioned2018-03-29T01:20:45Z
dc.date.available2018-03-29T01:20:45Z
dc.identifierColloids And Surfaces. B, Biointerfaces. v. 119, p. 82-9, 2014-Jul.
dc.identifier1873-4367
dc.identifier10.1016/j.colsurfb.2014.03.043
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24819430
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201392
dc.identifier24819430
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301625
dc.descriptionThe mesoporous SBA-15 silica with uniform hexagonal pore, narrow pore size distribution and tuneable pore diameter was organofunctionalized with glutaraldehyde-bridged silylating agent. The precursor and its derivative silicas were ibuprofen-loaded for controlled delivery in simulated biological fluids. The synthesized silicas were characterized by elemental analysis, infrared spectroscopy, (13)C and (29)Si solid state NMR spectroscopy, nitrogen adsorption, X-ray diffractometry, thermogravimetry and scanning electron microscopy. Surface functionalization with amine containing bridged hydrophobic structure resulted in significantly decreased surface area from 802.4 to 63.0 m(2) g(-1) and pore diameter 8.0-6.0 nm, which ultimately increased the drug-loading capacity from 18.0% up to 28.3% and a very slow release rate of ibuprofen over the period of 72.5h. The in vitro drug release demonstrated that SBA-15 presented the fastest release from 25% to 27% and SBA-15GA gave near 10% of drug release in all fluids during 72.5 h. The Korsmeyer-Peppas model better fits the release data with the Fickian diffusion mechanism and zero order kinetics for synthesized mesoporous silicas. Both pore sizes and hydrophobicity influenced the rate of the release process, indicating that the chemically modified silica can be suggested to design formulation of slow and constant release over a defined period, to avoid repeated administration.
dc.description119
dc.description82-9
dc.languageeng
dc.relationColloids And Surfaces. B, Biointerfaces
dc.relationColloids Surf B Biointerfaces
dc.rightsfechado
dc.rightsCopyright © 2014 Elsevier B.V. All rights reserved.
dc.sourcePubMed
dc.subjectAnti-inflammatory Agents, Non-steroidal
dc.subjectCross-linking Reagents
dc.subjectDelayed-action Preparations
dc.subjectDiffusion
dc.subjectDrug Compounding
dc.subjectGlutaral
dc.subjectHydrophobic And Hydrophilic Interactions
dc.subjectIbuprofen
dc.subjectKinetics
dc.subjectParticle Size
dc.subjectPorosity
dc.subjectSilanes
dc.subjectSilicon Dioxide
dc.subjectSurface Properties
dc.subjectDrug Delivery
dc.subjectGlutaraldehyde
dc.subjectIbuprofen
dc.subjectMesoporous Silica
dc.subjectOrganofunctionalization
dc.titleThe Applicability Of Ordered Mesoporous Sba-15 And Its Hydrophobic Glutaraldehyde-bridge Derivative To Improve Ibuprofen-loading In Releasing System.
dc.typeArtículos de revistas


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