The Intrahippocampal Infusion Of Crotamine From Crotalus Durissus Terrificus Venom Enhances Memory Persistence In Rats.

dc.creatorVargas, Liane S
dc.creatorLara, Marcus V S
dc.creatorGonçalves, Rithiele
dc.creatorMandredini, Vanusa
dc.creatorPonce-Soto, Luis Alberto
dc.creatorMarangoni, Sergio
dc.creatorDal Belo, Cháriston A
dc.creatorMello-Carpes, Pâmela B
dc.date2014-Jul
dc.date2015-11-27T13:42:30Z
dc.date2015-11-27T13:42:30Z
dc.date.accessioned2018-03-29T01:20:43Z
dc.date.available2018-03-29T01:20:43Z
dc.identifierToxicon : Official Journal Of The International Society On Toxinology. v. 85, p. 52-8, 2014-Jul.
dc.identifier1879-3150
dc.identifier10.1016/j.toxicon.2014.04.017
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24813333
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201389
dc.identifier24813333
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301622
dc.descriptionPrevious research has shown that crotamine, a toxin isolated from the venom of Crotalus durissus terrificus, induces the release of acetylcholine and dopamine in the central nervous system of rats. Particularly, these neurotransmitters are important modulators of memory processes. Therefore, in this study we investigated the effects of crotamine infusion on persistence of memory in rats. We verified that the intrahippocampal infusion of crotamine (1 μg/μl; 1 μl/side) improved the persistence of object recognition and aversive memory. By other side, the intrahippocampal infusion of the toxin did not alter locomotor and exploratory activities, anxiety or pain threshold. These results demonstrate a future prospect of using crotamine as potential pharmacological tool to treat diseases involving memory impairment, although it is still necessary more researches to better elucidate the crotamine effects on hippocampus and memory.
dc.description85
dc.description52-8
dc.languageeng
dc.relationToxicon : Official Journal Of The International Society On Toxinology
dc.relationToxicon
dc.rightsfechado
dc.rightsCopyright © 2014 Elsevier Ltd. All rights reserved.
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAvoidance Learning
dc.subjectBehavior, Animal
dc.subjectCa1 Region, Hippocampal
dc.subjectCrotalid Venoms
dc.subjectCrotalus
dc.subjectExploratory Behavior
dc.subjectHippocampus
dc.subjectInfusions, Intraventricular
dc.subjectMale
dc.subjectMaze Learning
dc.subjectMemory, Long-term
dc.subjectMotor Activity
dc.subjectNeurons
dc.subjectNeurotoxins
dc.subjectNootropic Agents
dc.subjectPain Threshold
dc.subjectRats, Wistar
dc.subjectRecognition (psychology)
dc.subjectInhibitory Avoidance Memory
dc.subjectObject Recognition Memory
dc.subjectSnake Venom
dc.subjectToxin
dc.titleThe Intrahippocampal Infusion Of Crotamine From Crotalus Durissus Terrificus Venom Enhances Memory Persistence In Rats.
dc.typeArtículos de revistas


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