The Value Of The 2005 International Society Of Urological Pathology (isup) Modified Gleason Grading System As A Predictor Of Biochemical Recurrence After Radical Prostatectomy.

dc.creatorBillis, Athanase
dc.creatorQuintal, Maisa M Q
dc.creatorMeirelles, Luciana
dc.creatorFreitas, Leandro L L
dc.creatorCosta, Larissa B E
dc.creatorBonfitto, João F L
dc.creatorDiniz, Betina L
dc.creatorPoletto, Paola H
dc.creatorMagna, Luís A
dc.creatorFerreira, Ubirajara
dc.date2014-May
dc.date2015-11-27T13:42:30Z
dc.date2015-11-27T13:42:30Z
dc.date.accessioned2018-03-29T01:20:43Z
dc.date.available2018-03-29T01:20:43Z
dc.identifierInternational Urology And Nephrology. v. 46, n. 5, p. 935-40, 2014-May.
dc.identifier1573-2584
dc.identifier10.1007/s11255-013-0579-8
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24096373
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201386
dc.identifier24096373
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301619
dc.descriptionTo compare time and risk to biochemical recurrence (BR) after radical prostatectomy of two chronologically different groups of patients using the standard and the modified Gleason system (MGS). Cohort 1 comprised biopsies of 197 patients graded according to the standard Gleason system (SGS) in the period 1997/2004, and cohort 2, 176 biopsies graded according to the modified system in the period 2005/2011. Time to BR was analyzed with the Kaplan-Meier product-limit analysis and prediction of shorter time to recurrence using univariate and multivariate Cox proportional hazards model. Patients in cohort 2 reflected time-related changes: striking increase in clinical stage T1c, systematic use of extended biopsies, and lower percentage of total length of cancer in millimeter in all cores. The MGS used in cohort 2 showed fewer biopsies with Gleason score ≤ 6 and more biopsies of the intermediate Gleason score 7. Time to BR using the Kaplan-Meier curves showed statistical significance using the MGS in cohort 2, but not the SGS in cohort 1. Only the MGS predicted shorter time to BR on univariate analysis and on multivariate analysis was an independent predictor. The results favor that the 2005 International Society of Urological Pathology modified system is a refinement of the Gleason grading and valuable for contemporary clinical practice.
dc.description46
dc.description935-40
dc.languageeng
dc.relationInternational Urology And Nephrology
dc.relationInt Urol Nephrol
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectBiopsy, Needle
dc.subjectCarcinoma
dc.subjectHumans
dc.subjectKaplan-meier Estimate
dc.subjectMale
dc.subjectNeoplasm Grading
dc.subjectNeoplasm Recurrence, Local
dc.subjectPractice Guidelines As Topic
dc.subjectProportional Hazards Models
dc.subjectProstate
dc.subjectProstate-specific Antigen
dc.subjectProstatectomy
dc.subjectProstatic Neoplasms
dc.subjectRetrospective Studies
dc.subjectRisk Assessment
dc.subjectTime Factors
dc.titleThe Value Of The 2005 International Society Of Urological Pathology (isup) Modified Gleason Grading System As A Predictor Of Biochemical Recurrence After Radical Prostatectomy.
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución