Impairment Of Thrombin Generation In The Early Phases Of The Host Response Of Sepsis.

dc.creatorPicoli-Quaino, Susan K
dc.creatorAlves, Brunna E
dc.creatorFaiotto, Vanessa B
dc.creatorMontalvao, Silmara A L
dc.creatorDe Souza, Carmino A
dc.creatorAnnichino-Bizzacchi, Joyce M
dc.creatorDe Paula, Erich V
dc.date2014-Feb
dc.date2015-11-27T13:42:25Z
dc.date2015-11-27T13:42:25Z
dc.date.accessioned2018-03-29T01:20:35Z
dc.date.available2018-03-29T01:20:35Z
dc.identifierJournal Of Critical Care. v. 29, n. 1, p. 31-6, 2014-Feb.
dc.identifier1557-8615
dc.identifier10.1016/j.jcrc.2013.08.015
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24075296
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201353
dc.identifier24075296
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301586
dc.descriptionThe purpose was to investigate the presence of hypercoagulability in the very early phase of the host response to an infection in the clinical course of sepsis and septic shock. Twenty-four patients with chemotherapy-associated febrile neutropenia were evaluated at baseline, at the time of fever onset, and 48 hours thereafter using the thrombin generation test, a more physiological and global assay of hemostasis. The rate of thrombin generation was decreased and no signals of systemic hypercoagulability could be observed during the first 48 hours of sepsis. Moreover, patients that evolved to septic shock presented a more significant impairment in thrombin generation than those with noncomplicated sepsis. Patients with sepsis and febrile neutropenia present an impairment in thrombin generation from very early stages of their disease course. These results suggest that the procoagulant in vitro alterations described during sepsis do not necessarily translate into a clinically relevant systemic hypercoagulable state. These findings could help explain why treatment with systemic anticoagulants did not translate to clinical benefits in human sepsis and highlight the need for a better understanding of the hemostatic alterations in sepsis before new treatments targeting coagulation activation are developed.
dc.description29
dc.description31-6
dc.languageeng
dc.relationJournal Of Critical Care
dc.relationJ Crit Care
dc.rightsfechado
dc.rights© 2013.
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectBiological Markers
dc.subjectBlood Coagulation Tests
dc.subjectChemotherapy-induced Febrile Neutropenia
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectOrgan Dysfunction Scores
dc.subjectSepsis
dc.subjectShock, Septic
dc.subjectThrombin
dc.subjectTime Factors
dc.subjectYoung Adult
dc.subjectDisseminated Intravascular Coagulation
dc.subjectSepsis
dc.subjectThrombin Generation
dc.titleImpairment Of Thrombin Generation In The Early Phases Of The Host Response Of Sepsis.
dc.typeArtículos de revistas


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