Anti-adhesion And Antibacterial Activity Of Silver Nanoparticles Supported On Graphene Oxide Sheets.

dc.creatorde Faria, Andreia Fonseca
dc.creatorMartinez, Diego Stéfani Teodoro
dc.creatorMeira, Stela Maris Meister
dc.creatorde Moraes, Ana Carolina Mazarin
dc.creatorBrandelli, Adriano
dc.creatorFilho, Antonio Gomes Souza
dc.creatorAlves, Oswaldo Luiz
dc.date2014-Jan
dc.date2015-11-27T13:42:22Z
dc.date2015-11-27T13:42:22Z
dc.date.accessioned2018-03-29T01:20:30Z
dc.date.available2018-03-29T01:20:30Z
dc.identifierColloids And Surfaces. B, Biointerfaces. v. 113, p. 115-24, 2014-Jan.
dc.identifier1873-4367
dc.identifier10.1016/j.colsurfb.2013.08.006
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24060936
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201331
dc.identifier24060936
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301564
dc.descriptionThis work reports on the preparation, characterization and antibacterial activity of a nanocomposite formed from graphene oxide (GO) sheets decorated with silver nanoparticles (GO-Ag). The GO-Ag nanocomposite was prepared in the presence of AgNO3 and sodium citrate. The physicochemical characterization was performed by UV-vis spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA), Raman spectroscopy and transmission electron microscopy (TEM). The average size of the silver nanoparticles anchored on the GO surface was 7.5 nm. Oxidation debris fragments (a byproduct adsorbed on the GO surface) were found to be crucial for the nucleation and growth of the silver nanoparticles. The antibacterial activity of the GO and GO-Ag nanocomposite against the microorganism Pseudomonas aeruginosa was investigated using the standard counting plate methodology. The GO dispersion showed no antibacterial activity against P. aeruginosa over the concentration range investigated. On the other hand, the GO-Ag nanocomposite displayed high biocidal activity with a minimum inhibitory concentration ranging from 2.5 to 5.0 μg/mL. The anti-biofilm activity toward P. aeruginosa adhered on stainless steel surfaces was also investigated. The results showed a 100% inhibition rate of the adhered cells after exposure to the GO-Ag nanocomposite for one hour. To the best of our knowledge, this work provides the first direct evidence that GO-Ag nanocomposites can inhibit the growth of microbial adhered cells, thus preventing the process of biofilm formation. These promising results support the idea that GO-Ag nanocomposites may be applied as antibacterial coatings material to prevent the development of biofilms in food packaging and medical devices.
dc.description113
dc.description115-24
dc.languageeng
dc.relationColloids And Surfaces. B, Biointerfaces
dc.relationColloids Surf B Biointerfaces
dc.rightsfechado
dc.rightsCopyright © 2013 Elsevier B.V. All rights reserved.
dc.sourcePubMed
dc.subjectAnti-bacterial Agents
dc.subjectGraphite
dc.subjectMetal Nanoparticles
dc.subjectMicrobial Sensitivity Tests
dc.subjectOxides
dc.subjectPseudomonas Aeruginosa
dc.subjectSilver
dc.subjectAntibacterial Activity
dc.subjectBiofilm
dc.subjectGraphene Oxide
dc.subjectNanocomposites
dc.subjectPseudomonas Aeruginosa
dc.subjectSilver Nanoparticles
dc.titleAnti-adhesion And Antibacterial Activity Of Silver Nanoparticles Supported On Graphene Oxide Sheets.
dc.typeArtículos de revistas


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