Analysis Of Myb Oncogene In Transformed Adenoid Cystic Carcinomas Reveals Distinct Pathways Of Tumor Progression.

dc.creatorCosta, Ana F
dc.creatorAltemani, Albina
dc.creatorGarcía-Inclán, Cristina
dc.creatorFresno, Florentino
dc.creatorSuárez, Carlos
dc.creatorLlorente, José L
dc.creatorHermsen, Mario
dc.date2014-Jun
dc.date2015-11-27T13:42:20Z
dc.date2015-11-27T13:42:20Z
dc.date.accessioned2018-03-29T01:20:26Z
dc.date.available2018-03-29T01:20:26Z
dc.identifierLaboratory Investigation; A Journal Of Technical Methods And Pathology. v. 94, n. 6, p. 692-702, 2014-Jun.
dc.identifier1530-0307
dc.identifier10.1038/labinvest.2014.59
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24732452
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201318
dc.identifier24732452
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301551
dc.descriptionAdenoid cystic carcinomas can occasionally undergo dedifferentiation, a phenomenon also referred to as high-grade transformation. However, cases of adenoid cystic carcinomas have been described showing transformation to adenocarcinomas that are not poorly differentiated, indicating that high-grade transformation may not necessarily reflect a more advanced stage of tumor progression, but rather a transformation to another histological form, which may encompass a wide spectrum of carcinomas in terms of aggressiveness. The aim of this study was to gain more insight in the biology of this pathological phenomenon by means of genetic profiling of both histological components. Using microarray comparative genomic hybridization, we compared the genome-wide DNA copy-number changes of the conventional and transformed area of eight adenoid cystic carcinomas with high-grade transformation, comprising four with transformation into moderately differentiated adenocarcinomas and four into poorly differentiated carcinomas. In general, the poorly differentiated carcinoma cases showed a higher total number of copy-number changes than the moderately differentiated adenocarcinoma cases, and this correlated with a worse clinical course. Special attention was given to chromosomal translocation and protein expression of MYB, recently being considered to be an early and major oncogenic event in adenoid cystic carcinomas. Our data showed that the process of high-grade transformation is not always accompanied by an accumulation of genetic alterations; both conventional and transformed components harbored unique genetic alterations, which indicate a parallel progression. Our data further demonstrated that the MYB/NFIB translocation is not necessarily an early event or fundamental for the progression to adenoid cystic carcinoma with high-grade transformation.
dc.description94
dc.description692-702
dc.languageeng
dc.relationLaboratory Investigation; A Journal Of Technical Methods And Pathology
dc.relationLab. Invest.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdult
dc.subjectCarcinoma, Adenoid Cystic
dc.subjectCell Dedifferentiation
dc.subjectCell Transformation, Neoplastic
dc.subjectComparative Genomic Hybridization
dc.subjectDna Copy Number Variations
dc.subjectDisease Progression
dc.subjectFemale
dc.subjectGenes, Myb
dc.subjectHumans
dc.subjectIn Situ Hybridization, Fluorescence
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMouth Neoplasms
dc.subjectTranslocation, Genetic
dc.titleAnalysis Of Myb Oncogene In Transformed Adenoid Cystic Carcinomas Reveals Distinct Pathways Of Tumor Progression.
dc.typeArtículos de revistas


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