Effects Of Different Intensities Of Physical Exercise On Insulin Sensitivity And Protein Kinase B/akt Activity In Skeletal Muscle Of Obese Mice.

dc.creatorMarinho, Rodolfo
dc.creatorMoura, Leandro Pereira de
dc.creatorRodrigues, Bárbara de Almeida
dc.creatorPauli, Luciana Santos Souza
dc.creatorSilva, Adelino Sanchez Ramos da
dc.creatorRopelle, Eloize Cristina Chiarreotto
dc.creatorSouza, Claudio Teodoro de
dc.creatorCintra, Dennys Esper Corrêa
dc.creatorRopelle, Eduardo Rochete
dc.creatorPauli, José Rodrigo
dc.date
dc.date2015-11-27T13:42:20Z
dc.date2015-11-27T13:42:20Z
dc.date.accessioned2018-03-29T01:20:25Z
dc.date.available2018-03-29T01:20:25Z
dc.identifierEinstein (são Paulo, Brazil). v. 12, n. 1, p. 82-9
dc.identifier2317-6385
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24728251
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201312
dc.identifier24728251
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301545
dc.descriptionTo investigate the effects of different intensities of acute exercise on insulin sensitivity and protein kinase B/Akt activity in skeletal muscle of obese mice. Swiss mice were randomly divided into four groups, and fed either a standard diet (control group) or high fat diet (obese sedentary group and obese exercise group 1 and 2) for 12 weeks. Two different exercise protocols were used: swimming for 1 hour with or without an overload of 5% body weight. The insulin tolerance test was performed to estimate whole-body sensitivity. Western blot technique was used to determine protein levels of protein kinase B/Akt and phosphorylation by protein Kinase B/Akt in mice skeletal muscle. A single bout of exercise inhibited the high fat diet-induced insulin resistance. There was increase in phosphorylation by protein kinase B/Akt serine, improve in insulin signaling and reduce of fasting glucose in mice that swam for 1 hour without overload and mice that swan for 1 hour with overload of 5%. However, no significant differences were seen between exercised groups. Regardless of intensity, aerobic exercise was able to improve insulin sensitivity and phosphorylation by protein kinase B/Ak, and proved to be a good form of treatment and prevention of type 2 diabetes.
dc.description12
dc.description82-9
dc.languageeng
dc.relationEinstein (são Paulo, Brazil)
dc.relationEinstein (Sao Paulo)
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBlood Glucose
dc.subjectBlotting, Western
dc.subjectDiabetes Mellitus, Type 2
dc.subjectDiet, High-fat
dc.subjectEnzyme-linked Immunosorbent Assay
dc.subjectInsulin
dc.subjectInsulin Resistance
dc.subjectMale
dc.subjectMice
dc.subjectMice, Obese
dc.subjectMuscle, Skeletal
dc.subjectObesity
dc.subjectPhosphorylation
dc.subjectPhysical Conditioning, Animal
dc.subjectProto-oncogene Proteins C-akt
dc.subjectRandom Allocation
dc.subjectTime Factors
dc.titleEffects Of Different Intensities Of Physical Exercise On Insulin Sensitivity And Protein Kinase B/akt Activity In Skeletal Muscle Of Obese Mice.
dc.typeArtículos de revistas


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