Artículos de revistas
Novel R-(+)-limonene-based Thiosemicarbazones And Their Antitumor Activity Against Human Tumor Cell Lines.
Registro en:
European Journal Of Medicinal Chemistry. v. 79, p. 110-6, 2014-May.
1768-3254
10.1016/j.ejmech.2014.03.086
24727464
Autor
Vandresen, Fábio
Falzirolli, Hugo
Almeida Batista, Sabrina A
da Silva-Giardini, Ana Paula B
de Oliveira, Diogo N
Catharino, Rodrigo R
Ruiz, Ana Lúcia T G
de Carvalho, João E
Foglio, Mary Ann
da Silva, Cleuza Conceição
Institución
Resumen
In an attempt to develop potent and selective antitumor agents, a series of novel thiosemicarbazones derived from a natural monoterpene R-(+)-limonene was synthesized and their antitumor activity was evaluated. Overall, the majority of tested compounds exhibited considerable inhibitory effects on the growth of a wide range of cancer cell lines. Almost all of tested thiosemicarbazones were especially sensitive to prostate cells (PC-3). Derivatives 5, 6, 8, 9, 10, 11 and 13 presented the most potent antitumor activity against PC-3 cells. These compounds showed lower value of GI50 (0.04-0.05 μM) than the reference drug paclitaxel, besides a high selectivity for the same cell line. The 4-fluorobenzaldehyde derivative 10 was the most selective compound for prostate cells, while 2-hydroxybenzaldehyde derivative 8 was the most active compound, with potent antitumor activity against all tested cell lines. 79 110-6