Infrared Imaging Spectroscopy And Chemometric Tools For In Situ Analysis Of An Imiquimod Pharmaceutical Preparation Presented As Cream.

dc.creatorCarneiro, Renato Lajarim
dc.creatorPoppi, Ronei Jesus
dc.date2014-Jan
dc.date2015-11-27T13:42:16Z
dc.date2015-11-27T13:42:16Z
dc.date.accessioned2018-03-29T01:20:22Z
dc.date.available2018-03-29T01:20:22Z
dc.identifierSpectrochimica Acta. Part A, Molecular And Biomolecular Spectroscopy. v. 118, p. 215-20, 2014-Jan.
dc.identifier1873-3557
dc.identifier10.1016/j.saa.2013.08.104
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24051293
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201298
dc.identifier24051293
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301531
dc.descriptionIn the present work the homogeneity of a pharmaceutical formulation presented as a cream was studied using infrared imaging spectroscopy and chemometric methodologies such as principal component analysis (PCA) and multivariate curve resolution with alternating least squares (MCR-ALS). A cream formulation, presented as an emulsion, was prepared using imiquimod as the active pharmaceutical ingredient (API) and the excipients: water, vaseline, an emulsifier and a carboxylic acid in order to dissolve the API. After exposure at 45°C during 3 months to perform accelerated stability test, the presence of some crystals was observed, indicating homogeneity problems in the formulation. PCA exploratory analysis showed that the crystal composition was different from the composition of the emulsion, since the score maps presented crystal structures in the emulsion. MCR-ALS estimated the spectra of the crystals and the emulsion. The crystals presented amine and C-H bands, suggesting that the precipitate was a salt formed by carboxylic acid and imiquimod. These results indicate the potential of infrared imaging spectroscopy in conjunction with chemometric methodologies as an analytical tool to ensure the quality of cream formulations in the pharmaceutical industry.
dc.description118
dc.description215-20
dc.languageeng
dc.relationSpectrochimica Acta. Part A, Molecular And Biomolecular Spectroscopy
dc.relationSpectrochim Acta A Mol Biomol Spectrosc
dc.rightsfechado
dc.rightsCopyright © 2013 Elsevier B.V. All rights reserved.
dc.sourcePubMed
dc.subjectAminoquinolines
dc.subjectLeast-squares Analysis
dc.subjectMultivariate Analysis
dc.subjectPrincipal Component Analysis
dc.subjectSkin Cream
dc.subjectSpectrophotometry, Infrared
dc.subjectSpectroscopy, Near-infrared
dc.subjectImiquimod
dc.subjectInfrared Imaging Spectroscopy
dc.subjectMultivariate Curve Resolution
dc.subjectPharmaceutical Formulations Analysis
dc.subjectPrincipal Component Analysis
dc.titleInfrared Imaging Spectroscopy And Chemometric Tools For In Situ Analysis Of An Imiquimod Pharmaceutical Preparation Presented As Cream.
dc.typeArtículos de revistas


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