Increased 27-hydroxycholesterol Plasma Level In Men With Low High Density Lipoprotein-cholesterol May Circumvent Their Reduced Cell Cholesterol Efflux Rate.

dc.creatorNunes, Valéria S
dc.creatorPanzoldo, Natália B
dc.creatorLeança, Camila C
dc.creatorParra, Eliane S
dc.creatorZago, Vanessa S
dc.creatorda Silva, Eliton J
dc.creatorCazita, Patrícia M
dc.creatorNakandakare, Edna R
dc.creatorde Faria, Eliana C
dc.creatorQuintão, Eder C R
dc.date2014-Jun
dc.date2015-11-27T13:42:09Z
dc.date2015-11-27T13:42:09Z
dc.date.accessioned2018-03-29T01:20:10Z
dc.date.available2018-03-29T01:20:10Z
dc.identifierClinica Chimica Acta; International Journal Of Clinical Chemistry. v. 433, p. 169-73, 2014-Jun.
dc.identifier1873-3492
dc.identifier10.1016/j.cca.2014.03.017
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24657483
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201245
dc.identifier24657483
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301478
dc.descriptionHDL is considered the most important mechanism for the excretion of intracellular cholesterol. The liver is the only organ capable to metabolize cholesterol into bile acid. The enzymatic conversion of cholesterol to bile acid is dependent on the cytochrome P450 microsomal system which is also responsible for the generation of oxysterols. The latter's plasma concentrations may reflect the metabolic processes of specific tissues where they are generated. The objective of this study was to investigate in healthy individuals who differ according to their HDL levels the concentration of oxysterols and relate it to the HDL-dependent cell cholesterol efflux rate. 24-Hydroxycholesterol, 25-hydroxycholesterol, 27-hydroxycholesterol were determined in plasma by GLC/mass spectrometry in 107 healthy subjects with low HDL (HDL-C<1.03mmol/l) and high HDL cholesterol (HDL-C>1.55mmol/l). HDL-dependent in vitro cell cholesterol efflux rate was measured in 29 cases. No differences were found in plasma oxysterol concentrations between the Low HDL and High HDL groups. There was a significant negative correlation between HDL-C and 27-hydroxycholesterol. Plasma oxysterol concentrations were significantly lower in female than in male subjects. The Low HDL male group had higher 27-hydroxycholesterol than the High HDL male group. Cell cholesterol efflux rate was lower in Low HDL than in High HDL and related inversely with 27-hydroxycholesterol. As compared to High HDL, Low HDL men have increased 27-hydroxycholesterol plasma level that may circumvent their reduced cell cholesterol efflux rate.
dc.description433
dc.description169-73
dc.languageeng
dc.relationClinica Chimica Acta; International Journal Of Clinical Chemistry
dc.relationClin. Chim. Acta
dc.rightsfechado
dc.rightsCopyright © 2014 Elsevier B.V. All rights reserved.
dc.sourcePubMed
dc.subjectAdult
dc.subjectBiological Transport
dc.subjectCholesterol, Hdl
dc.subjectFemale
dc.subjectHealthy Volunteers
dc.subjectHumans
dc.subjectHydroxycholesterols
dc.subjectLiver
dc.subjectMale
dc.subject24-hydroxycholesterol
dc.subject25-hydroxycholesterol
dc.subject27-hydroxycholesterol
dc.subjectCell Cholesterol Efflux
dc.subjectHdl-c
dc.titleIncreased 27-hydroxycholesterol Plasma Level In Men With Low High Density Lipoprotein-cholesterol May Circumvent Their Reduced Cell Cholesterol Efflux Rate.
dc.typeArtículos de revistas


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