Analysis Of Surgical Margins In Oral Cancer Using In Situ Fluorescence Spectroscopy.

dc.creatorFrancisco, Ana Lucia Noronha
dc.creatorCorrer, Wagner Rafael
dc.creatorPinto, Clóvis Antônio Lopes
dc.creatorGonçalves Filho, João
dc.creatorChulam, Thiago Celestino
dc.creatorKurachi, Cristina
dc.creatorKowalski, Luiz Paulo
dc.date2014-Jun
dc.date2015-11-27T13:42:07Z
dc.date2015-11-27T13:42:07Z
dc.date.accessioned2018-03-29T01:20:06Z
dc.date.available2018-03-29T01:20:06Z
dc.identifierOral Oncology. v. 50, n. 6, p. 593-9, 2014-Jun.
dc.identifier1879-0593
dc.identifier10.1016/j.oraloncology.2014.02.008
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24630901
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201226
dc.identifier24630901
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301459
dc.descriptionOral cancer is a public health problem with high prevalence in the population. Local tumor control is best achieved by complete surgical resection with adequate margins. A disease-free surgical margin correlates with a lower rate of local recurrence and a higher rate of disease-free survival. Fluorescence spectroscopy is a noninvasive diagnostic tool that can aid in real-time cancer detection. The technique, which evaluates the biochemical composition and structure of tissue fluorescence, is relatively simple, fast and, accurate. This study aimed to compare oral squamous cell carcinoma lesions to surgical margins and the mucosa of healthy volunteers by fluorescence spectroscopy. The sample consisted of 56 individuals, 28 with oral squamous cell carcinoma and 28 healthy volunteers with normal oral mucosa. Thirty six cases (64.3%) were male and the mean age was 60.9 years old. The spectra were classified and compared to histopathology to determine fluorescence efficiency for diagnostic discrimination of tumors. In the analysis of the other cases we observed discrimination between normal mucosa, injury and margins. At two-year follow up, three individuals had local recurrence, and in two cases investigation fluorescence in the corresponding area showed qualitative differences in spectra between the recurrence area and the area without recurrence at the same anatomical site in the same patient. In situ analysis of oral mucosa showed the potential of fluorescence spectroscopy as a diagnostic tool that can aid in discrimination of altered mucosa and normal mucosa.
dc.description50
dc.description593-9
dc.languageeng
dc.relationOral Oncology
dc.relationOral Oncol.
dc.rightsfechado
dc.rightsCopyright © 2014 Elsevier Ltd. All rights reserved.
dc.sourcePubMed
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 And Over
dc.subjectAlcohol Drinking
dc.subjectCase-control Studies
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMouth Neoplasms
dc.subjectSmoking
dc.subjectSpectrometry, Fluorescence
dc.subjectDiagnosis
dc.subjectFluorescence Spectroscopy
dc.subjectOral Cavity
dc.subjectSquamous Cell Carcinoma
dc.subjectSurgical Margins
dc.titleAnalysis Of Surgical Margins In Oral Cancer Using In Situ Fluorescence Spectroscopy.
dc.typeArtículos de revistas


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