Tribulus Terrestris Versus Placebo In The Treatment Of Erectile Dysfunction: A Prospective, Randomized, Double Blind Study.

dc.creatorSantos, C A
dc.creatorReis, L O
dc.creatorDestro-Saade, R
dc.creatorLuiza-Reis, A
dc.creatorFregonesi, A
dc.date2014-May
dc.date2015-11-27T13:42:07Z
dc.date2015-11-27T13:42:07Z
dc.date.accessioned2018-03-29T01:20:05Z
dc.date.available2018-03-29T01:20:05Z
dc.identifierActas Urologicas Españolas. v. 38, n. 4, p. 244-8, 2014-May.
dc.identifier1699-7980
dc.identifier10.1016/j.acuro.2013.09.014
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24630840
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201225
dc.identifier24630840
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301458
dc.descriptionTo evaluate the possible effects of Tribulus terrestris herbal medicine in the erectile dysfunction treatment and to quantify its potential impact on serum testosterone levels. Prospective, randomized, double-blind and placebo-controlled study including thirty healthy men selected from 100 patients who presented themselves spontaneously complaining of erectile dysfunction, ≥ 40 years of age, nonsmokers, not undergoing treatment for prostate cancer or erectile dysfunction, no dyslipidemia, no phosphodiesterase inhibitor use, no hormonal manipulation and, if present hypertension and/or diabetes mellitus should be controlled. International Index of Erectile Function (IIEF-5) and serum testosterone were obtained before randomization and after 30 days of study. Patients were randomized into two groups of fifteen subjects each. The study group received 800 mg of Tribulus terrestris, divided into two doses per day for thirty days and the control group received placebo administered in the same way. The groups were statistically equivalent in all aspects evaluated. The mean (SD) age was 60 (9.4) and 62.9 (7.9), P = .36 for intervention and placebo groups, respectively. Before treatment, the intervention group showed mean IIEF-5 of 13.2 (5-21) and mean total testosterone 417.1 ng/dl (270.7-548.4 ng/dl); the placebo group showed mean IIEF-5 of 11.6 (6-21) and mean total testosterone 442.7 ng/dl (301-609.1 ng/dl). After treatment, the intervention group showed mean IIEF-5 of 15.3 (5-21) and mean total testosterone 409.3 ng/dl (216.9-760.8 ng/dl); the placebo group showed mean IIEF-5 of 13.7 (6-21) and mean total testosterone 466.3 ng/dl (264.3-934.3 ng/dl). The time factor caused statistically significant changes in both groups for IIEF-5 only (P = .0004), however, there was no difference between the two groups (P = .7914). At the dose and interval studied, Tribulus terrestris was not more effective than placebo on improving symptoms of erectile dysfunction or serum total testosterone.
dc.description38
dc.description244-8
dc.languageeng
dc.languagespa
dc.relationActas Urologicas Españolas
dc.relationActas Urol Esp
dc.rightsfechado
dc.rightsCopyright © 2013 AEU. Published by Elsevier Espana. All rights reserved.
dc.sourcePubMed
dc.subjectAlternative Medicine
dc.subjectDisfunción Sexual
dc.subjectFitoterapia
dc.subjectHerbal Medicine
dc.subjectImpotence
dc.subjectImpotencia
dc.subjectLibido
dc.subjectMedicina Alternativa
dc.subjectPlacebo And Chinese Medicine
dc.subjectPlacebo Y Medicina China
dc.subjectSexual Dysfunction
dc.subjectTestosterona
dc.subjectTestosterone
dc.titleTribulus Terrestris Versus Placebo In The Treatment Of Erectile Dysfunction: A Prospective, Randomized, Double Blind Study.
dc.typeArtículos de revistas


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