In Situ Assessment Of Atorvastatin Impurity Using Maldi Mass Spectrometry Imaging (maldi-msi).

dc.creatorRodrigues, Lívia Riberti
dc.creatorde Oliveira, Diogo Noin
dc.creatorFerreira, Mônica Siqueira
dc.creatorCatharino, Rodrigo Ramos
dc.date2014-Mar
dc.date2015-11-27T13:42:06Z
dc.date2015-11-27T13:42:06Z
dc.date.accessioned2018-03-29T01:20:03Z
dc.date.available2018-03-29T01:20:03Z
dc.identifierAnalytica Chimica Acta. v. 818, p. 32-8, 2014-Mar.
dc.identifier1873-4324
dc.identifier10.1016/j.aca.2014.01.050
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24626400
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201217
dc.identifier24626400
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301450
dc.descriptionThe analysis of impurities and degradation products in pharmaceutical preparations are usually performed by chromatographic techniques such as high-performance liquid chromatography (HPLC). This approach demands extensive analysis time, mostly due to extraction and separation phases. These steps must be carried out in samples in order to adapt them to the requirements of the analytical method of choice. In the present contribution, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was employed to quantify an important degradation product in atorvastatin calcium 80 mg tablets: the atorvastatin lactone. Through the standard of the impurity, it was possible to perform quantitative analysis directly on the drug tablet, using a quick and novel approach, suitable for quality control processes in the pharmaceutical industry.
dc.description818
dc.description32-8
dc.languageeng
dc.relationAnalytica Chimica Acta
dc.relationAnal. Chim. Acta
dc.rightsfechado
dc.rightsCopyright © 2014 Elsevier B.V. All rights reserved.
dc.sourcePubMed
dc.subjectChemistry Techniques, Analytical
dc.subjectChromatography, High Pressure Liquid
dc.subjectHeptanoic Acids
dc.subjectPyrroles
dc.subjectSpectrometry, Mass, Matrix-assisted Laser Desorption-ionization
dc.subjectTablets
dc.subjectTemperature
dc.subjectTime Factors
dc.subjectAtorvastatin
dc.subjectImpurities
dc.subjectMass Spectrometry Imaging
dc.subjectQuality Control
dc.titleIn Situ Assessment Of Atorvastatin Impurity Using Maldi Mass Spectrometry Imaging (maldi-msi).
dc.typeArtículos de revistas


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