Default Mode, Executive Function, And Language Functional Connectivity Networks Are Compromised In Mild Alzheimer's Disease.

dc.creatorWeiler, Marina
dc.creatorFukuda, Aya
dc.creatorMassabki, Lilian H P
dc.creatorLopes, Tatila M
dc.creatorFranco, Alexandre R
dc.creatorDamasceno, Benito P
dc.creatorCendes, Fernando
dc.creatorBalthazar, Marcio L F
dc.date2014-Mar
dc.date2015-11-27T13:41:52Z
dc.date2015-11-27T13:41:52Z
dc.date.accessioned2018-03-29T01:19:39Z
dc.date.available2018-03-29T01:19:39Z
dc.identifierCurrent Alzheimer Research. v. 11, n. 3, p. 274-82, 2014-Mar.
dc.identifier1875-5828
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24484280
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201115
dc.identifier24484280
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301348
dc.descriptionAlzheimer's disease (AD) is characterized by mental and cognitive problems, particularly with memory, language, visuospatial skills (VS), and executive functions (EF). Advances in the neuroimaging of AD have highlighted dysfunctions in functional connectivity networks (FCNs), especially in the memory related default mode network (DMN). However, little is known about the integrity and clinical significance of FNCs that process other cognitive functions than memory. We evaluated 22 patients with mild AD and 26 healthy controls through a resting state functional MRI scan. We aimed to identify different FCNs: the DMN, language, EF, and VS. Seed-based functional connectivity was calculated by placing a seed in the DMN (posterior cingulate cortex), language (Broca's and Wernicke's areas), EF (right and left dorsolateral prefrontal cortex), and VS networks (right and left associative visual cortex). We also performed regression analyses between individual connectivity maps for the different FCNs and the scores on cognitive tests. We found areas with significant decreases in functional connectivity in patients with mild AD in the DMN and Wernicke's area compared with controls. Increased connectivity in patients was observed in the EF network. Regarding multiple linear regression analyses, a significant correlation was only observed between the connectivity of the DMN and episodic memory (delayed recall) scores. In conclusion, functional connectivity alterations in mild AD are not restricted to the DMN. Other FCNs related to language and EF may be altered. However, we only found significant correlations between cognition and functional connectivity in the DMN and episodic memory performance.
dc.description11
dc.description274-82
dc.languageeng
dc.relationCurrent Alzheimer Research
dc.relationCurr Alzheimer Res
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAged
dc.subjectAged, 80 And Over
dc.subjectAlzheimer Disease
dc.subjectBrain
dc.subjectBrain Mapping
dc.subjectExecutive Function
dc.subjectFemale
dc.subjectHumans
dc.subjectImage Processing, Computer-assisted
dc.subjectLanguage
dc.subjectMagnetic Resonance Imaging
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMild Cognitive Impairment
dc.subjectNeural Pathways
dc.subjectNeuropsychological Tests
dc.subjectPeroxides
dc.subjectUrea
dc.titleDefault Mode, Executive Function, And Language Functional Connectivity Networks Are Compromised In Mild Alzheimer's Disease.
dc.typeArtículos de revistas


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