Understanding The Beneficial Effects Of Doxycycline On The Dystrophic Phenotype Of The Mdx Mouse.

dc.creatorPereira, Juliano Alves
dc.creatorMatsumura, Cintia Yuri
dc.creatorMinatel, Elaine
dc.creatorMarques, Maria Julia
dc.creatorSanto Neto, Humberto
dc.date2014-Aug
dc.date2015-11-27T13:41:47Z
dc.date2015-11-27T13:41:47Z
dc.date.accessioned2018-03-29T01:19:35Z
dc.date.available2018-03-29T01:19:35Z
dc.identifierMuscle & Nerve. v. 50, n. 2, p. 283-6, 2014-Aug.
dc.identifier1097-4598
dc.identifier10.1002/mus.24177
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24435758
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201096
dc.identifier24435758
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301329
dc.descriptionThe purpose of this study was to better understand the beneficial effects of doxycycline on the dystrophic muscles of the mdx mouse. Doxycycline (DOX) was administered for 36 days, starting on postnatal day 0, via drinking water. Untreated mdx mice received plain water for the same period and served as a control group. DOX decreased the levels of metalloproteinase-9 and tumor necrosis factor-alpha in the biceps brachii and diaphragm of the mdx mice. It also reduced the total amount of calcium in the muscles studied, concomitant with an increase in the levels of calsequestrin 1. The results show that DOX can affect factors that are important in dystrophic pathogenesis and highlight its potential as a readily accessible therapy in clinical trials for treatment of Duchenne muscular dystrophy.
dc.description50
dc.description283-6
dc.languageeng
dc.relationMuscle & Nerve
dc.relationMuscle Nerve
dc.rightsfechado
dc.rights© 2014 Wiley Periodicals, Inc.
dc.sourcePubMed
dc.subjectAldehydes
dc.subjectAnimals
dc.subjectAnti-bacterial Agents
dc.subjectCalcium
dc.subjectCalcium-binding Proteins
dc.subjectDoxycycline
dc.subjectGene Expression Regulation
dc.subjectMatrix Metalloproteinase 9
dc.subjectMice
dc.subjectMice, Inbred C57bl
dc.subjectMice, Inbred Mdx
dc.subjectMuscular Dystrophy, Animal
dc.subjectTime Factors
dc.subjectTumor Necrosis Factor-alpha
dc.subjectDmd
dc.subjectTnf-α
dc.subjectCalsequestrin 1
dc.subjectDoxycycline
dc.subjectMdx
dc.subjectMetalloproteinase-9
dc.titleUnderstanding The Beneficial Effects Of Doxycycline On The Dystrophic Phenotype Of The Mdx Mouse.
dc.typeArtículos de revistas


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