Stathmin 1 Is Involved In The Highly Proliferative Phenotype Of High-risk Myelodysplastic Syndromes And Acute Leukemia Cells.

dc.creatorMachado-Neto, João Agostinho
dc.creatorde Melo Campos, Paula
dc.creatorFavaro, Patricia
dc.creatorLazarini, Mariana
dc.creatorLorand-Metze, Irene
dc.creatorCosta, Fernando Ferreira
dc.creatorOlalla Saad, Sara Teresinha
dc.creatorTraina, Fabiola
dc.date2014-Feb
dc.date2015-11-27T13:41:39Z
dc.date2015-11-27T13:41:39Z
dc.date.accessioned2018-03-29T01:19:24Z
dc.date.available2018-03-29T01:19:24Z
dc.identifierLeukemia Research. v. 38, n. 2, p. 251-7, 2014-Feb.
dc.identifier1873-5835
dc.identifier10.1016/j.leukres.2013.11.013
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24355524
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201049
dc.identifier24355524
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301282
dc.descriptionStathmin 1 is an important cytoplasmic microtubule-destabilizing protein that plays critical roles in proliferation and accurate chromosome segregation through regulation of microtubule dynamics. High levels of Stathmin 1 expression have been reported in leukemia and solid tumors. However, Stathmin 1 has not been studied in myelodysplastic syndrome cells. We, herein, report that significantly higher Stathmin 1 levels were observed in proliferating hematopoietic cells, in high-risk MDS and acute leukemia cells. In addition, Stathmin 1 silencing in U937 and Namalwa leukemia cells reduced cell proliferation and clonogenicity. Our data suggest that Stathmin 1 expression may be related to the highly proliferative phenotype of hematopoietic cells and add new insights into the participation of Stathmin 1 in hematological malignancies.
dc.description38
dc.description251-7
dc.languageeng
dc.relationLeukemia Research
dc.relationLeuk. Res.
dc.rightsfechado
dc.rightsCopyright © 2013 Elsevier Ltd. All rights reserved.
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 And Over
dc.subjectCell Proliferation
dc.subjectFemale
dc.subjectHumans
dc.subjectLeukemia, Myeloid, Acute
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMyelodysplastic Syndromes
dc.subjectNeoplasm Invasiveness
dc.subjectPhenotype
dc.subjectRisk
dc.subjectStathmin
dc.subjectTumor Cells, Cultured
dc.subjectU937 Cells
dc.subjectYoung Adult
dc.subjectAcute Lymphoid Leukemia
dc.subjectAcute Myeloid Leukemia
dc.subjectMyelodysplastic Syndromes
dc.subjectOp18
dc.subjectStathmin 1
dc.titleStathmin 1 Is Involved In The Highly Proliferative Phenotype Of High-risk Myelodysplastic Syndromes And Acute Leukemia Cells.
dc.typeArtículos de revistas


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