Chlorella Vulgaris Treatment Ameliorates The Suppressive Effects Of Single And Repeated Stressors On Hematopoiesis.

dc.creatorQueiroz, Julia de Souza
dc.creatorBarbosa, Christiano M V
dc.creatorRocha, Michelle C da
dc.creatorBincoletto, Claudia
dc.creatorParedes-Gamero, Edgar J
dc.creatorQueiroz, Mary L de Souza
dc.creatorPalermo Neto, João
dc.date2013-Mar
dc.date2015-11-27T13:32:39Z
dc.date2015-11-27T13:32:39Z
dc.date.accessioned2018-03-29T01:19:17Z
dc.date.available2018-03-29T01:19:17Z
dc.identifierBrain, Behavior, And Immunity. v. 29, p. 39-50, 2013-Mar.
dc.identifier1090-2139
dc.identifier10.1016/j.bbi.2012.12.001
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23246529
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201022
dc.identifier23246529
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301255
dc.descriptionThe reports regarding the mutual influence between the central nervous system and the immune system constitute a vast and somewhat controversial body of literature. Stress is known to disturb homeostasis, impairing immunological functions. In this study, we investigated the hematopoietic response of Chlorella vulgaris (CV)-treated mice exposed to single (SST) and repeated stress (RST). We observed a reduction in the numbers of hematopoietic progenitors (HP) in the bone marrow and long-term bone marrow cultures (LTBMC) using flow cytometry and a coinciding decrease in the number of granulocyte-macrophage colonies (CFU-GM) after treatment with both stressors, but SST caused a more profound suppression. We observed a proportional increase in the colony-stimulating activity (CSA) of the serum of animals subjected to SST or RST. In the bone marrow, SST and RST induced a decrease in both mature myeloid and lymphoid populations but did not affect pluripotent hematopoietic progenitors (Lin(-)Sca-1(+)c-kit(+), LSK), and again, a more profound suppression was observed after SST. We further quantified the levels of interleukin-1α (IL-1α) and interleukin-6 (IL-6) and the number of myeloid cells in LTBMC. Both SST and RST reduced the levels of these cytokines to similar degrees. The myeloid population was also reduced in LTBMC, and SST induced a more intense suppression. Importantly, CV treatment prevented the changes produced by SST and RST in all of the parameters evaluated. Together, our results suggest that CV treatment is an effective tool for the prophylaxis of myelosuppression caused by single or repeated stressors.
dc.description29
dc.description39-50
dc.languageeng
dc.relationBrain, Behavior, And Immunity
dc.relationBrain Behav. Immun.
dc.rightsfechado
dc.rightsCopyright © 2012 Elsevier Inc. All rights reserved.
dc.sourcePubMed
dc.subjectAnimals
dc.subjectBone Marrow
dc.subjectBone Marrow Cells
dc.subjectChlorella Vulgaris
dc.subjectFlow Cytometry
dc.subjectGranulocyte-macrophage Colony-stimulating Factor
dc.subjectHematopoiesis
dc.subjectInterleukin-1alpha
dc.subjectInterleukin-6
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectMyeloid Cells
dc.subjectStem Cells
dc.subjectStress, Psychological
dc.titleChlorella Vulgaris Treatment Ameliorates The Suppressive Effects Of Single And Repeated Stressors On Hematopoiesis.
dc.typeArtículos de revistas


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