Effects Of Fish Oil Containing Eicosapentaenoic Acid And Docosahexaenoic Acid On Dystrophic Mdx Mice.

dc.creatorFogagnolo Mauricio, Adriana
dc.creatorMinatel, Elaine
dc.creatorSanto Neto, Humberto
dc.creatorMarques, Maria Julia
dc.date2013-Aug
dc.date2015-11-27T13:32:38Z
dc.date2015-11-27T13:32:38Z
dc.date.accessioned2018-03-29T01:19:16Z
dc.date.available2018-03-29T01:19:16Z
dc.identifierClinical Nutrition (edinburgh, Scotland). v. 32, n. 4, p. 636-42, 2013-Aug.
dc.identifier1532-1983
dc.identifier10.1016/j.clnu.2012.11.013
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23218947
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201015
dc.identifier23218947
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301248
dc.descriptionIn Duchenne muscular dystrophy (DMD) and in the mdx mouse model of DMD, the lack of dystrophin leads to muscle degeneration and inflammation contributes to progression of the disease. In this study, we evaluated the effects of commercially available fish oil containing EPA and docosahexaenoic acid (DHA) on mdx. Mdx mice (14 days old) were treated with fish oil (FDC Vitamins; 0.002 g EPA and 0.001 g DHA) for 16 days by gavage. Control mdx mice received mineral oil (Nujol). Grip strength measurement was used for functional evaluation. The sternomastoid, diaphragm and biceps brachii muscles were removed and processed for histopathology and Western blot analysis. Fish oil decreased creatine kinase and myonecrosis. In all muscles studied, the inflammatory area was significantly reduced after treatment (18.0 ± 3.0% inflammatory area in untreated mdx mice versus 4.0 ± 1% in treated mdx mice). Fish oil protected against the loss of muscle strength. Fish oil significantly reduced the levels of TNF-α and the levels of 4-HNE-protein adducts (30-34% reduction for both) in all muscles studied. Commercially available fish oil may be potentially useful to ameliorate dystrophic progression of skeletal muscles, deserving further clinical trials in DMD patients.
dc.description32
dc.description636-42
dc.languageeng
dc.relationClinical Nutrition (edinburgh, Scotland)
dc.relationClin Nutr
dc.rightsfechado
dc.rightsCopyright © 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCreatine Kinase
dc.subjectDiaphragm
dc.subjectDisease Models, Animal
dc.subjectDocosahexaenoic Acids
dc.subjectDystrophin
dc.subjectEicosapentaenoic Acid
dc.subjectFemale
dc.subjectFish Oils
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred C57bl
dc.subjectMice, Inbred Mdx
dc.subjectMuscle Strength
dc.subjectMuscle, Skeletal
dc.subjectMuscular Dystrophy, Animal
dc.subjectMuscular Dystrophy, Duchenne
dc.subjectTumor Necrosis Factor-alpha
dc.titleEffects Of Fish Oil Containing Eicosapentaenoic Acid And Docosahexaenoic Acid On Dystrophic Mdx Mice.
dc.typeArtículos de revistas


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