Prostate Total Tumor Extent Versus Index Tumor Extent--which Is Predictive Of Biochemical Recurrence Following Radical Prostatectomy?

dc.creatorBillis, Athanase
dc.creatorMeirelles, Luciana R
dc.creatorFreitas, Leandro L L
dc.creatorPolidoro, Aline S
dc.creatorFernandes, Hamilton A
dc.creatorPadilha, Mariana M
dc.creatorMagna, Luis A
dc.creatorFerreira, Ubirajara
dc.date2013-Jan
dc.date2015-11-27T13:32:36Z
dc.date2015-11-27T13:32:36Z
dc.date.accessioned2018-03-29T01:19:13Z
dc.date.available2018-03-29T01:19:13Z
dc.identifierThe Journal Of Urology. v. 189, n. 1, p. 99-104, 2013-Jan.
dc.identifier1527-3792
dc.identifier10.1016/j.juro.2012.08.179
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23164377
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/201000
dc.identifier23164377
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301233
dc.descriptionIt is controversial whether tumor extent in radical prostatectomies predicts biochemical recurrence following surgery. We compared the predictive value of total tumor extent vs dominant nodule (index tumor) extent. A mean of 32 paraffin blocks was processed from prostate surgical specimens step sectioned at 3 to 5 mm intervals from 300 patients treated with radical retropubic prostatectomy. Each transverse section was subdivided into 2 anterolateral and 2 posterolateral quadrants. Tumor extent was evaluated by a semiquantitative point count method. Dominant nodule extent was recorded as the maximal number of positive points of the largest single focus of cancer in the quadrants. Time to biochemical recurrence was analyzed by Kaplan-Meier product limit analysis. Prediction of shorter time to biochemical recurrence was determined by univariate and multivariate Cox proportional hazards models. Except for age and race, total and index tumor extent was significantly associated with higher preoperative prostate specific antigen, clinical stage T2, pathological stage greater than T2, positive surgical margins and higher radical prostatectomy Gleason score. Total and index tumor extent was significantly associated with time to biochemical recurrence in Kaplan-Meier estimates. Total and index tumor extent significantly predicted shorter time to biochemical recurrence on univariate analysis but only index tumor extent was an independent predictor of time to biochemical recurrence on multivariate analysis. The study indicates that any tumor extent estimate in surgical specimens should be related to the dominant nodule (index tumor) and not to total tumor extent.
dc.description189
dc.description99-104
dc.languageeng
dc.relationThe Journal Of Urology
dc.relationJ. Urol.
dc.rightsfechado
dc.rightsCopyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
dc.sourcePubMed
dc.subjectAdult
dc.subjectAged
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasm Recurrence, Local
dc.subjectPredictive Value Of Tests
dc.subjectProstate-specific Antigen
dc.subjectProstatectomy
dc.subjectProstatic Neoplasms
dc.subjectRetrospective Studies
dc.titleProstate Total Tumor Extent Versus Index Tumor Extent--which Is Predictive Of Biochemical Recurrence Following Radical Prostatectomy?
dc.typeArtículos de revistas


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