Differences In Estrogen And Progesterone Receptor Expression In Endometrial Polyps And Atrophic Endometrium Of Postmenopausal Women With And Without Exposure To Tamoxifen.

dc.creatorLeão, Rogerio Barros Ferreira
dc.creatorAndrade, Liliana
dc.creatorVassalo, Jose
dc.creatorAntunes, Armando
dc.creatorPinto-Neto, Aarão
dc.creatorCosta-Paiva, Lucia
dc.date2013-Nov
dc.date2015-11-27T13:32:31Z
dc.date2015-11-27T13:32:31Z
dc.date.accessioned2018-03-29T01:19:07Z
dc.date.available2018-03-29T01:19:07Z
dc.identifierMolecular And Clinical Oncology. v. 1, n. 6, p. 1055-1060, 2013-Nov.
dc.identifier2049-9450
dc.identifier10.3892/mco.2013.180
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24649292
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200976
dc.identifier24649292
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301209
dc.descriptionPostmenopausal women who use tamoxifen present with an increased incidence of endometrial alterations, such as polyps and hyperplasia, in addition to a higher risk of malignant endometrial neoplasms. Among these endometrial changes, polyps are the most common, with a pathogenesis associated with hormonal influence. The objective of this study was to compare the expression of estrogen receptors (ERs) and progesterone receptors (PRs) in endometrial polyps from tamoxifen users with that in endometrial polyps and the atrophic endometrium of postmenopausal tamoxifen non-users. Among women undergoing surgical hysteroscopy, 84 tamoxifen users with benign endometrial polyps were selected. This group was compared to 84 samples of atrophic endometrium and to 252 benign polyps from postmenopausal women who were not treated with tamoxifen. The expression of ER/PR was assessed by immunohistochemical analysis, according to the percentage of stained cells, intensity of nuclear staining and final score. The polyps from tamoxifen users exhibited a higher expression of ER and PR in the glandular epithelium and stroma compared to the atrophic endometrium (P<0.0001). Compared to the polyps from women not treated with tamoxifen, tamoxifen users exhibited a higher PR expression in the epithelium (P=0.0014) and stroma (P=0.0056), with no difference in the expression of ER. In conclusion, endometrial polyps frequently exhibit an increase in ER expression, regardless of tamoxifen use. High levels of PR expression appear to be consistent with the estrogen agonist effects of tamoxifen.
dc.description1
dc.description1055-1060
dc.languageeng
dc.relationMolecular And Clinical Oncology
dc.relationMol Clin Oncol
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectEndometrial Polyp
dc.subjectEstrogen Receptor
dc.subjectProgesterone Receptor
dc.subjectTamoxifen
dc.titleDifferences In Estrogen And Progesterone Receptor Expression In Endometrial Polyps And Atrophic Endometrium Of Postmenopausal Women With And Without Exposure To Tamoxifen.
dc.typeArtículos de revistas


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