Subclinical Hypothyroidism In Young Women With Polycystic Ovary Syndrome: An Analysis Of Clinical, Hormonal, And Metabolic Parameters.

dc.creatorBenetti-Pinto, Cristina Laguna
dc.creatorBerini Piccolo, Vanessa Ribeiro Santana
dc.creatorGarmes, Heraldo Mendes
dc.creatorTeatin Juliato, Cássia Raquel
dc.date2013-Feb
dc.date2015-11-27T13:32:26Z
dc.date2015-11-27T13:32:26Z
dc.date.accessioned2018-03-29T01:18:59Z
dc.date.available2018-03-29T01:18:59Z
dc.identifierFertility And Sterility. v. 99, n. 2, p. 588-92, 2013-Feb.
dc.identifier1556-5653
dc.identifier10.1016/j.fertnstert.2012.10.006
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23103018
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200940
dc.identifier23103018
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301173
dc.descriptionTo analyze the relationship between selected clinical and metabolic parameters in young women with polycystic ovary syndrome (PCOS) and normal thyroid function or subclinical hypothyroidism (SCH). A cross-sectional cohort study. Tertiary care clinic. Women diagnosed with PCOS according to the Rotterdam criteria (n = 168). Clinical, hormonal, and metabolic parameters were evaluated. SCH was defined as TSH levels of 4.5-10 mIU/L. Separately, PCOS and SCH exert adverse effects on metabolic parameters; however, in conjunction their effect is unclear. This study evaluated whether SCH in women with PCOS affects clinical, hormonal, and metabolic parameters. The mean age of the 168 women was 24 ± 5.8 years. Mean body mass index was 33.4 ± 8.2 kg/m(2). Thyroid function was normal in 149 women, and 19 had SCH. Only serum low-density lipoprotein cholesterol and PRL levels were significantly higher in the women with SCH (122.6 ± 25.6 mg/dL and 17.7 ± 7.7 ng/mL, respectively) compared with those with normal thyroid function (105.6 ± 33 mg/dL and 14 ± 10.3 ng/mL, respectively). In young women with PCOS, SCH is associated with higher low-density lipoprotein cholesterol levels, albeit with no changes in other lipid profile parameters, insulin resistance, or phenotypic manifestations. This study adds to current evidence supporting an association between PCOS and SCH.
dc.description99
dc.description588-92
dc.languageeng
dc.relationFertility And Sterility
dc.relationFertil. Steril.
dc.rightsfechado
dc.rightsCopyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
dc.sourcePubMed
dc.subjectBiological Markers
dc.subjectBrazil
dc.subjectComorbidity
dc.subjectFemale
dc.subjectHumans
dc.subjectHypothyroidism
dc.subjectLipids
dc.subjectPolycystic Ovary Syndrome
dc.subjectPrevalence
dc.subjectRisk Factors
dc.subjectThyrotropin
dc.subjectYoung Adult
dc.titleSubclinical Hypothyroidism In Young Women With Polycystic Ovary Syndrome: An Analysis Of Clinical, Hormonal, And Metabolic Parameters.
dc.typeArtículos de revistas


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