| dc.creator | Hirata, Fabio Endo | |
| dc.creator | Vasconcellos, José Paulo Cabral de | |
| dc.creator | Medina, Flávio MacCord | |
| dc.creator | Rim, Priscila Hae Hyun | |
| dc.creator | Fulco, Enzo Augusto Medeiros | |
| dc.creator | Melo, Mônica Barbosa de | |
| dc.date | 2013-Dec | |
| dc.date | 2015-11-27T13:32:25Z | |
| dc.date | 2015-11-27T13:32:25Z | |
| dc.date.accessioned | 2018-03-29T01:18:58Z | |
| dc.date.available | 2018-03-29T01:18:58Z | |
| dc.identifier | Ophthalmic Genetics. , p. 1-5, 2013-Dec. | |
| dc.identifier | 1744-5094 | |
| dc.identifier | 10.3109/13816810.2013.867449 | |
| dc.identifier | http://www.ncbi.nlm.nih.gov/pubmed/24372405 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/200936 | |
| dc.identifier | 24372405 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1301169 | |
| dc.description | Abstract Background: An association between LOC387715/ARMS2 (rs10490924) gene polymorphism and AMD has been reported. The aim of this study was to evaluate whether this polymorphism is associated with AMD in a Brazilian cohort. Materials and Methods: In total, 126 unrelated AMD patients (mean age 74.17 ± 7.64) were compared with 86 healthy controls (mean age 71.82 ± 7.12). Study subjects were classified according to the International ARM Epidemiological Study Group definition for early and late-stage AMD. LOC387715/ARMS2 rs10490924 polymorphism was evaluated through polymerase chain reaction and direct sequencing. Results: The T allele frequency was significantly higher in AMD patients than in controls (39.6% compared to 20.3%). The odds ratio (OR) for AMD was 2.05 (95% CI 1.13-3.71) for heterozygotes (TG) and 8.32 (95% CI 2.30-45.99) for homozygotes (TT). Conclusions: These results suggest that there is a contribution of the rs10490924 SNP of the LOC387715/ARMS2 gene to AMD susceptibility in this sample of the Brazilian population. | |
| dc.description | | |
| dc.description | 1-5 | |
| dc.language | eng | |
| dc.relation | Ophthalmic Genetics | |
| dc.relation | Ophthalmic Genet. | |
| dc.rights | fechado | |
| dc.rights | | |
| dc.source | PubMed | |
| dc.subject | Amd | |
| dc.subject | Loc387715/arms2 | |
| dc.subject | Macular Degeneration | |
| dc.subject | Polymorphism | |
| dc.subject | Rs10490924 | |
| dc.title | Association Of Loc387715/arms2 (rs10490924) Gene Polymorphism With Age-related Macular Degeneration In The Brazilian Population. | |
| dc.type | Artículos de revistas | |
