Ptk2 And Ptpn11 Expression In Myelodysplastic Syndromes.

dc.creatorLazarini, Mariana
dc.creatorMachado-Neto, João Agostinho
dc.creatorArchangelo, Leticia Fröhlich
dc.creatorMendes-Silva, Bruna Fernandes
dc.creatorBigarella, Carolina Louzão
dc.creatorTraina, Fabiola
dc.creatorSaad, Sara Teresinha Olalla
dc.date2013-Oct
dc.date2015-11-27T13:32:19Z
dc.date2015-11-27T13:32:19Z
dc.date.accessioned2018-03-29T01:18:46Z
dc.date.available2018-03-29T01:18:46Z
dc.identifierClinics (são Paulo, Brazil). v. 68, n. 10, p. 1371-5, 2013-Oct.
dc.identifier1980-5322
dc.identifier10.6061/clinics/2013(10)13
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24212846
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200886
dc.identifier24212846
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301119
dc.descriptionThe aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes. Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions were analyzed by quantitative polymerase chain reaction in bone marrow cells from patients with myelodysplastic syndromes and healthy donors. Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions did not significantly differ between normal cells and myelodysplastic cells. Our data suggest that despite the relevance of focal adhesion kinase and src homology 2 domain-containing protein-tyrosine phosphatase 2 in hematopoietic disorders, their mRNA expression do not significantly differ between total bone marrow cells from patients with myelodysplastic syndromes and healthy donors.
dc.description68
dc.description1371-5
dc.languageeng
dc.relationClinics (são Paulo, Brazil)
dc.relationClinics (Sao Paulo)
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 And Over
dc.subjectBone Marrow Cells
dc.subjectFemale
dc.subjectFocal Adhesion Kinase 2
dc.subjectFocal Adhesion Protein-tyrosine Kinases
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMyelodysplastic Syndromes
dc.subjectPolymerase Chain Reaction
dc.subjectPrognosis
dc.subjectProtein Tyrosine Phosphatase, Non-receptor Type 11
dc.subjectRisk Factors
dc.subjectStatistics, Nonparametric
dc.subjectYoung Adult
dc.subjectSrc Homology Domains
dc.titlePtk2 And Ptpn11 Expression In Myelodysplastic Syndromes.
dc.typeArtículos de revistas


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