Gold(i)-phosphine-n-heterocycles: Biological Activity And Specific (ligand) Interactions On The C-terminal Hivncp7 Zinc Finger.

dc.creatorAbbehausen, Camilla
dc.creatorPeterson, Erica J
dc.creatorde Paiva, Raphael E F
dc.creatorCorbi, Pedro P
dc.creatorFormiga, André L B
dc.creatorQu, Yun
dc.creatorFarrell, Nicholas P
dc.date2013-Oct
dc.date2015-11-27T13:32:11Z
dc.date2015-11-27T13:32:11Z
dc.date.accessioned2018-03-29T01:18:33Z
dc.date.available2018-03-29T01:18:33Z
dc.identifierInorganic Chemistry. v. 52, n. 19, p. 11280-7, 2013-Oct.
dc.identifier1520-510X
dc.identifier10.1021/ic401535s
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24063530
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200826
dc.identifier24063530
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301059
dc.descriptionThe syntheses and the characterization by chemical analysis, (1)H and (31)P NMR spectroscopy, and mass spectrometry of a series of linear triphenylphosphine gold(I) complexes with substituted N-heterocycle ligands (L), [(PPh3)Au(I)(L)](+), is reported. The reaction of [(PPh3)Au(L)](+) (L = Cl(-) or substituted N- heterocyclic pyridine) with the C-terminal (Cys3His) finger of HIVNCp7 shows evidence by mass spectrometry (ESI-MS) and (31)P NMR spectroscopy of a long-lived {(PPh3)Au}-S-peptide species resulting from displacement of the chloride or pyridine ligand by zinc-bound cysteine with concomitant displacement of Zn(2+). In contrast, reactions with the Cys2His2 finger-3 of the Sp1 transcription factor shows significantly reduced intensities of {(PPh3)Au} adducts. The results suggest the possibility of systematic (electronic, steric) variations of carrier group PR3 and leaving group L as well as the nature of the zinc finger in modulation of biological activity. The cytotoxicity, cell cycle signaling effects, and cellular accumulation of the series are also reported. All compounds display cytotoxicity in the micromolar range upon 96 h continuous exposure to human tumor cells. The results may have relevance for the reported inhibition of viral load in simian virus by the gold(I) drug auranofin.
dc.description52
dc.description11280-7
dc.languageeng
dc.relationInorganic Chemistry
dc.relationInorg Chem
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectCell Line, Tumor
dc.subjectCell Proliferation
dc.subjectCircular Dichroism
dc.subjectGold
dc.subjectHeterocyclic Compounds
dc.subjectHumans
dc.subjectInhibitory Concentration 50
dc.subjectLigands
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectPhosphines
dc.subjectSpectrometry, Mass, Electrospray Ionization
dc.subjectZinc Fingers
dc.subjectGag Gene Products, Human Immunodeficiency Virus
dc.titleGold(i)-phosphine-n-heterocycles: Biological Activity And Specific (ligand) Interactions On The C-terminal Hivncp7 Zinc Finger.
dc.typeArtículos de revistas


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