Guava Pomace: A New Source Of Anti-inflammatory And Analgesic Bioactives.

dc.creatorDenny, Carina
dc.creatorMelo, Priscilla S
dc.creatorFranchin, Marcelo
dc.creatorMassarioli, Adna P
dc.creatorBergamaschi, Keityane B
dc.creatorde Alencar, Severino M
dc.creatorRosalen, Pedro L
dc.date2013
dc.date2015-11-27T13:32:11Z
dc.date2015-11-27T13:32:11Z
dc.date.accessioned2018-03-29T01:18:32Z
dc.date.available2018-03-29T01:18:32Z
dc.identifierBmc Complementary And Alternative Medicine. v. 13, p. 235, 2013.
dc.identifier1472-6882
dc.identifier10.1186/1472-6882-13-235
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/24063346
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200824
dc.identifier24063346
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301057
dc.descriptionGuava pomace is an example of the processing waste generated after the manufacturing process from the juice industry that could be a source of bioactives. Thus, the present investigation was carried out in order to evaluate the anti-inflammatory and antinociceptive potential and determinate the main phenolic compounds of a guava pomace extract (GPE). The anti-inflammatory activity was evaluated by carrageenan, dextran, serotonin, histamine-induced paw edema and neutrophils migration in the peritoneal cavity models. Acetic acid-induced abdominal writhing and formalin test were performed to investigate the antinociceptive effects. In addition, the content of total phenolic and of individual phenolic compounds was determined by GC/MS. GPE showed anti-inflammatory activity by carrageenan, dextran, serotonin, histamine-induced paw edema and neutrophils migration in the peritoneal cavity models (p < 0.05). GPE also demonstrated antinociceptive activity by acetic acid-induced abdominal writhing and formalin test (p < 0.05). The total phenolic value was 3.40 ± 0.09 mg GAE/g and epicatechin, quercetin, myricetin, isovanilic and gallic acids were identified by GC/MS analysis. The presence of bioactive phenolic compounds as well as important effects demonstrated in animal models suggest that guava pomace could be an interesting source of anti-inflammatory and analgesic substances.
dc.description13
dc.description235
dc.languageeng
dc.relationBmc Complementary And Alternative Medicine
dc.relationBMC Complement Altern Med
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnalgesics
dc.subjectAnimals
dc.subjectAnti-inflammatory Agents
dc.subjectBehavior, Animal
dc.subjectFormaldehyde
dc.subjectIndustrial Waste
dc.subjectMale
dc.subjectMice
dc.subjectMice, Inbred Balb C
dc.subjectNeutrophils
dc.subjectPain Measurement
dc.subjectPeritoneal Cavity
dc.subjectPlant Extracts
dc.subjectPsidium
dc.titleGuava Pomace: A New Source Of Anti-inflammatory And Analgesic Bioactives.
dc.typeArtículos de revistas


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