Mammary Analogue Secretory Carcinoma Of Salivary Glands Is A Lipid-rich Tumour, And Adipophilin Can Be Valuable In Its Identification.

dc.creatorMariano, Fernanda Viviane
dc.creatordos Santos, Harim Tavares
dc.creatorAzañero, Wilson Delgado
dc.creatorda Cunha, Isabela Werneck
dc.creatorCoutinho-Camilo, Claudia Malheiros
dc.creatorde Almeida, Oslei Paes
dc.creatorKowalski, Luiz Paulo
dc.creatorAltemani, Albina
dc.date2013-Oct
dc.date2015-11-27T13:32:04Z
dc.date2015-11-27T13:32:04Z
dc.date.accessioned2018-03-29T01:18:21Z
dc.date.available2018-03-29T01:18:21Z
dc.identifierHistopathology. v. 63, n. 4, p. 558-67, 2013-Oct.
dc.identifier1365-2559
dc.identifier10.1111/his.12192
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23931576
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200777
dc.identifier23931576
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1301010
dc.descriptionMammary analogue secretory carcinoma (MASC) of salivary glands shows morphological similarities to milk-secreting mammary epithelial cells. The aim of this study was to analyse the immunohistochemical expression of adipophilin (a component of milk lipid globule membranes) and of proteins related to secretory mechanisms (STAT5a and mammaglobin) in MASC and other salivary tumours. Ten cases of MASC (all with ETV6 translocation) and 83 other salivary carcinomas were studied. In all MASC cases, adipophilin stained numerous large lipid droplets. These droplets were minute in other salivary carcinomas, except for sebaceous carcinoma. Overexpression of STAT5a was detected in all MASC cases, but only occasionally in other carcinomas. Mammaglobin expression occurred frequently in MASC (70% of cases), whereas, in other carcinomas, it was uncommon and limited. Only MASC showed cytoplasmic reactivity for p63, particularly in papillary-cystic areas. Positivity for S100, vimentin and high molecular weight keratin was observed in 100% of MASC cases. MASC is a lipid-rich tumour containing large lipid droplets covered by adipophilin. This finding can be included among its defining immunohistochemical features, and possibly represents lactation-like secretory differentiation. Strong expression of STAT5a and cytoplasmic p63 in MASC reinforces this hypothesis.
dc.description63
dc.description558-67
dc.languageeng
dc.relationHistopathology
dc.relationHistopathology
dc.rightsfechado
dc.rights© 2013 John Wiley & Sons Ltd.
dc.sourcePubMed
dc.subjectAdult
dc.subjectAged
dc.subjectCarcinoma
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectIn Situ Hybridization, Fluorescence
dc.subjectMale
dc.subjectMembrane Proteins
dc.subjectMiddle Aged
dc.subjectOncogene Proteins, Fusion
dc.subjectSalivary Gland Neoplasms
dc.subjectTumor Markers, Biological
dc.subjectYoung Adult
dc.subjectAdipophilin
dc.subjectLipid-rich Tumour
dc.subjectMammary Analogue Secretory Carcinoma
dc.titleMammary Analogue Secretory Carcinoma Of Salivary Glands Is A Lipid-rich Tumour, And Adipophilin Can Be Valuable In Its Identification.
dc.typeArtículos de revistas


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