Blood Protein Adsorption On Sulfonated Chitosan And κ-carrageenan Films.

dc.creatorLima, Pedro H L
dc.creatorPereira, Saulo V A
dc.creatorRabello, Rodrigo B
dc.creatorRodriguez-Castellón, Enrique
dc.creatorBeppu, Marisa M
dc.creatorChevallier, Pascale
dc.creatorMantovani, Diego
dc.creatorVieira, Rodrigo S
dc.date2013-Nov
dc.date2015-11-27T13:32:02Z
dc.date2015-11-27T13:32:02Z
dc.date.accessioned2018-03-29T01:18:18Z
dc.date.available2018-03-29T01:18:18Z
dc.identifierColloids And Surfaces. B, Biointerfaces. v. 111, p. 719-25, 2013-Nov.
dc.identifier1873-4367
dc.identifier10.1016/j.colsurfb.2013.06.002
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23911741
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200765
dc.identifier23911741
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300998
dc.descriptionMany strategies have been reported to improve compatibility of biopolymers using chemical and physical modifications. One possibility is the introduction of sulfonate groups (R-SO3(-)) in the chitosan chain. Another biopolymer with similar characteristics to those of heparin is κ-carrageenan. This study proposed to investigate the application of these two polymers, based on their potential for globular protein adsorption (BSA and fibrinogen). Polymeric films of chitosan and κ-carrageenan were prepared; all films were characterized by elemental analyses, FTIR, XPS and SEM. Characterization techniques showed that the chitosan chain was modified and confirmed the existence of sulfonate groups, as well as in the κ-carrageenan chain, indicating surfaces with similar chemical properties to those of heparin. The effect of charge density was observed for each adsorption condition (BSA at pH 5.0 and 7.4). A more pronounced adsorption rate was observed at pH 5.0 than at pH 7.4 and equilibrium adsorption was achieved, in both cases, after approximately 20 min. The equilibrium data indicate a lower adsorption rate for the sulfonated chitosan film, in comparison to the other films. These results confirm the potential of modified chitosan for use in applications in which globular protein adsorption should be avoided.
dc.description111
dc.description719-25
dc.languageeng
dc.relationColloids And Surfaces. B, Biointerfaces
dc.relationColloids Surf B Biointerfaces
dc.rightsfechado
dc.rightsCopyright © 2013 Elsevier B.V. All rights reserved.
dc.sourcePubMed
dc.subjectAntithrombogenic
dc.subjectBlood Device
dc.subjectCarrageenan
dc.subjectChitosan
dc.subjectProtein Adsorption
dc.titleBlood Protein Adsorption On Sulfonated Chitosan And κ-carrageenan Films.
dc.typeArtículos de revistas


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