Chloroquine: Modes Of Action Of An Undervalued Drug.

dc.creatorThomé, Rodolfo
dc.creatorLopes, Stefanie Costa Pinto
dc.creatorCosta, Fabio Trindade Maranhão
dc.creatorVerinaud, Liana
dc.date2013-Jun
dc.date2015-11-27T13:32:00Z
dc.date2015-11-27T13:32:00Z
dc.date.accessioned2018-03-29T01:18:14Z
dc.date.available2018-03-29T01:18:14Z
dc.identifierImmunology Letters. v. 153, n. 1-2, p. 50-7, 2013-Jun.
dc.identifier1879-0542
dc.identifier10.1016/j.imlet.2013.07.004
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23891850
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200749
dc.identifier23891850
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300982
dc.descriptionFor more than two decades, chloroquine (CQ) was largely and deliberately used as first choice drug for malaria treatment. However, worldwide increasing cases of resistant strains of Plasmodium have hampered its use. Nevertheless, CQ has recently been tested as adjunct therapy in several inflammatory situations, such as rheumatoid arthritis and transplantation procedures, presenting intriguing and promising results. In this review, we discuss recent findings and CQ mechanisms of action vis-à-vis its use as a broad adjunct therapy.
dc.description153
dc.description50-7
dc.languageeng
dc.relationImmunology Letters
dc.relationImmunol. Lett.
dc.rightsfechado
dc.rightsCopyright © 2013 Elsevier B.V. All rights reserved.
dc.sourcePubMed
dc.subjectAnti-inflammatory Agents
dc.subjectArthritis, Rheumatoid
dc.subjectChloroquine
dc.subjectDrug Resistance, Bacterial
dc.subjectEye
dc.subjectHumans
dc.subjectImmunosuppressive Agents
dc.subjectLysosomes
dc.subjectMalaria
dc.subjectPlasmodium
dc.subjectTransplantation
dc.subjectTransplantation Immunology
dc.subjectAutoimmunity
dc.subjectChloroquine
dc.subjectMalaria
dc.subjectTransplantation
dc.titleChloroquine: Modes Of Action Of An Undervalued Drug.
dc.typeArtículos de revistas


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