Zoledronic Acid Decreases Gene Expression Of Vascular Endothelial Growth Factor And Basic Fibroblast Growth Factor By Human Epithelial Cells.

dc.creatorBasso, Fernanda G
dc.creatorTurrioni, Ana Paula S
dc.creatorHebling, Josimeri
dc.creatorde Souza Costa, Carlos Alberto
dc.date2013-Dec
dc.date2015-11-27T13:31:50Z
dc.date2015-11-27T13:31:50Z
dc.date.accessioned2018-03-29T01:17:58Z
dc.date.available2018-03-29T01:17:58Z
dc.identifierThe British Journal Of Oral & Maxillofacial Surgery. v. 51, n. 8, p. 971-3, 2013-Dec.
dc.identifier1532-1940
dc.identifier10.1016/j.bjoms.2013.05.010
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23773293
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200681
dc.identifier23773293
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300914
dc.descriptionDelayed wound healing in patients taking bisphosphonates could result from decreased expression of growth factors, which are directly related to cell proliferation and migration. In this study, we evaluated the gene expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) by epithelial cells exposed to zoledronic acid 5 μmol for 48 h using real-time polymerase chain reaction. The gene expression of VEGF and bFGF by epithelial cells exposed to zoledronic acid decreased by 34% and 51%, respectively (p=0.0001 and p=0.0001). We conclude that zoledronic acid can decrease the expression of growth factors by epithelial cells.
dc.description51
dc.description971-3
dc.languageeng
dc.relationThe British Journal Of Oral & Maxillofacial Surgery
dc.relationBr J Oral Maxillofac Surg
dc.rightsfechado
dc.rightsCopyright © 2013 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
dc.sourcePubMed
dc.subjectBisphosphonates
dc.subjectEpithelial Cells
dc.subjectTissue Healing
dc.subjectVegf
dc.subjectBfgf
dc.titleZoledronic Acid Decreases Gene Expression Of Vascular Endothelial Growth Factor And Basic Fibroblast Growth Factor By Human Epithelial Cells.
dc.typeArtículos de revistas


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