The Genome Of Anopheles Darlingi, The Main Neotropical Malaria Vector.

dc.creatorMarinotti, Osvaldo
dc.creatorCerqueira, Gustavo C
dc.creatorde Almeida, Luiz Gonzaga Paula
dc.creatorFerro, Maria Inês Tiraboschi
dc.creatorLoreto, Elgion Lucio da Silva
dc.creatorZaha, Arnaldo
dc.creatorTeixeira, Santuza M R
dc.creatorWespiser, Adam R
dc.creatorAlmeida E Silva, Alexandre
dc.creatorSchlindwein, Aline Daiane
dc.creatorPacheco, Ana Carolina Landim
dc.creatorSilva, Artur Luiz da Costa da
dc.creatorGraveley, Brenton R
dc.creatorWalenz, Brian P
dc.creatorLima, Bruna de Araujo
dc.creatorRibeiro, Carlos Alexandre Gomes
dc.creatorNunes-Silva, Carlos Gustavo
dc.creatorde Carvalho, Carlos Roberto
dc.creatorSoares, Célia Maria de Almeida
dc.creatorde Menezes, Claudia Beatriz Afonso
dc.creatorMatiolli, Cleverson
dc.creatorCaffrey, Daniel
dc.creatorAraújo, Demetrius Antonio M
dc.creatorde Oliveira, Diana Magalhães
dc.creatorGolenbock, Douglas
dc.creatorGrisard, Edmundo Carlos
dc.creatorFantinatti-Garboggini, Fabiana
dc.creatorde Carvalho, Fabíola Marques
dc.creatorBarcellos, Fernando Gomes
dc.creatorProsdocimi, Francisco
dc.creatorMay, Gemma
dc.creatorAzevedo Junior, Gilson Martins de
dc.creatorGuimarães, Giselle Moura
dc.creatorGoldman, Gustavo Henrique
dc.creatorPadilha, Itácio Q M
dc.creatorBatista, Jacqueline da Silva
dc.creatorFerro, Jesus Aparecido
dc.creatorRibeiro, José M C
dc.creatorFietto, Juliana Lopes Rangel
dc.creatorDabbas, Karina Maia
dc.creatorCerdeira, Louise
dc.creatorAgnez-Lima, Lucymara Fassarella
dc.creatorBrocchi, Marcelo
dc.creatorde Carvalho, Marcos Oliveira
dc.creatorTeixeira, Marcus de Melo
dc.creatorDiniz Maia, Maria de Mascena
dc.creatorGoldman, Maria Helena S
dc.creatorCruz Schneider, Maria Paula
dc.creatorFelipe, Maria Sueli Soares
dc.creatorHungria, Mariangela
dc.creatorNicolás, Marisa Fabiana
dc.creatorPereira, Maristela
dc.creatorMontes, Martín Alejandro
dc.creatorCantão, Maurício E
dc.creatorVincentz, Michel
dc.creatorRafael, Miriam Silva
dc.creatorSilverman, Neal
dc.creatorStoco, Patrícia Hermes
dc.creatorSouza, Rangel Celso
dc.creatorVicentini, Renato
dc.creatorGazzinelli, Ricardo Tostes
dc.creatorNeves, Rogério de Oliveira
dc.creatorSilva, Rosane
dc.creatorAstolfi-Filho, Spartaco
dc.creatorMaciel, Talles Eduardo Ferreira
dc.creatorUrményi, Turán P
dc.creatorTadei, Wanderli Pedro
dc.creatorCamargo, Erney Plessmann
dc.creatorde Vasconcelos, Ana Tereza Ribeiro
dc.date2013-Aug
dc.date2015-11-27T13:31:50Z
dc.date2015-11-27T13:31:50Z
dc.date.accessioned2018-03-29T01:17:57Z
dc.date.available2018-03-29T01:17:57Z
dc.identifierNucleic Acids Research. v. 41, n. 15, p. 7387-400, 2013-Aug.
dc.identifier1362-4962
dc.identifier10.1093/nar/gkt484
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23761445
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200678
dc.identifier23761445
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300911
dc.descriptionAnopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vector-human and vector-parasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles-darlingi.
dc.description41
dc.description7387-400
dc.languageeng
dc.relationNucleic Acids Research
dc.relationNucleic Acids Res.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectAnopheles
dc.subjectBrazil
dc.subjectChromosomes, Insect
dc.subjectDna Transposable Elements
dc.subjectEvolution, Molecular
dc.subjectFemale
dc.subjectGenetic Variation
dc.subjectGenome, Insect
dc.subjectHost-parasite Interactions
dc.subjectInsect Proteins
dc.subjectInsect Vectors
dc.subjectInsecticide Resistance
dc.subjectInsecticides
dc.subjectMalaria
dc.subjectMale
dc.subjectMolecular Sequence Annotation
dc.subjectPhylogeny
dc.subjectSynteny
dc.subjectTranscriptome
dc.titleThe Genome Of Anopheles Darlingi, The Main Neotropical Malaria Vector.
dc.typeArtículos de revistas


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