Skin Vasodilation And Analgesic Effect Of A Topical Nitric Oxide-releasing Hydrogel.

dc.creatorVercelino, Rafael
dc.creatorCunha, Thiago Mattar
dc.creatorFerreira, Elisa Silva
dc.creatorCunha, Fernando Q
dc.creatorFerreira, Sérgio H
dc.creatorde Oliveira, Marcelo G
dc.date2013-Sep
dc.date2015-11-27T13:31:49Z
dc.date2015-11-27T13:31:49Z
dc.date.accessioned2018-03-29T01:17:56Z
dc.date.available2018-03-29T01:17:56Z
dc.identifierJournal Of Materials Science. Materials In Medicine. v. 24, n. 9, p. 2157-69, 2013-Sep.
dc.identifier1573-4838
dc.identifier10.1007/s10856-013-4973-7
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/23756965
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200673
dc.identifier23756965
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300906
dc.descriptionNew approaches based on topical treatments are needed for treating pain and impaired dermal blood flow. We used a topical Pluronic F127 hydrogel containing S-nitrosoglutathione (GSNO) as a prodrug to generate free NO, an effector molecule that exerts both dermal vasodilation and antinociceptive effects. GSNO-containing hydrogels underwent gelation above 12 °C and released free NO at rates that were directly dependent on the GSNO concentration in the range of 50-150 mM. The topical application of this material led to dose-response dermal vasodilation in healthy volunteers and to a reduction of up to 50 % of the hypernociception intensity in Wistar rats that were subjected to inflammatory pain. Mechanistic investigations indicated that the antinociceptive effect of the topical F127/GSNO hydrogels is produced by the local activation of the cGMP/PKG/KATP channel-signaling pathway, which was stimulated by the free NO that diffused through the skin. These results expand the scope of the biomedical applications of this material and may represent a new approach for the topical treatment of inflammatory pain.
dc.description24
dc.description2157-69
dc.languageeng
dc.relationJournal Of Materials Science. Materials In Medicine
dc.relationJ Mater Sci Mater Med
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdministration, Topical
dc.subjectAdult
dc.subjectAnalgesics
dc.subjectAnimals
dc.subjectCalorimetry, Differential Scanning
dc.subjectDose-response Relationship, Drug
dc.subjectFemale
dc.subjectHumans
dc.subjectHydrogels
dc.subjectMale
dc.subjectNitric Oxide
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSkin
dc.subjectVasodilation
dc.subjectVasodilator Agents
dc.subjectYoung Adult
dc.titleSkin Vasodilation And Analgesic Effect Of A Topical Nitric Oxide-releasing Hydrogel.
dc.typeArtículos de revistas


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