Early Changes Of Hypothalamic Angiotensin Ii Receptors Expression In Gestational Protein-restricted Offspring: Effect On Water Intake, Blood Pressure And Renal Sodium Handling.

dc.creatorde Lima, Marcelo Cardoso
dc.creatorScabora, José Eduardo
dc.creatorLopes, Agnes
dc.creatorMesquita, Flávia Fernandes
dc.creatorTorres, Daniele
dc.creatorBoer, Patrícia Aline
dc.creatorGontijo, José Antonio Rocha
dc.date2013-Sep
dc.date2015-11-27T13:31:45Z
dc.date2015-11-27T13:31:45Z
dc.date.accessioned2018-03-29T01:17:50Z
dc.date.available2018-03-29T01:17:50Z
dc.identifierJournal Of The Renin-angiotensin-aldosterone System : Jraas. v. 14, n. 3, p. 271-82, 2013-Sep.
dc.identifier1752-8976
dc.identifier10.1177/1470320312456328
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/22936038
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/200643
dc.identifier22936038
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1300876
dc.descriptionThe current study examines changes in the postnatal hypothalamic angiotensin receptors by maternal protein restriction (LP), and its impact on in uteri programming of hypertension in adult life. The data show that LP male pup body weight was significantly reduced when compared to that of control (NP) pups. Also, immunoblotting analysis demonstrated a significantly decreased expression of type 1 AngII receptors (AT1R) in the entire hypothalamic tissue extract of LP rats at 12 days of age compared to age-matched NP offspring. Conversely, the expression of the type 2 AngII (AT2R) receptors in 12-day- and 16-week-old LP hypothalamus was significantly increased. The current data show the influence of central AngII administration on water consumption in a concentration-dependent fashion, but also demonstrate that the water intake response to AngII was strikingly attenuated in 16-week-old LP. These results may be related to decreased brain arginine vasopressin (AVP) expression appearing in maternal protein-restricted offspring. The present investigation shows an early decrease in fractional urinary sodium excretion in maternal protein-restricted offspring. The decreased fractional sodium excretion was accompanied by a fall in proximal sodium excretion and occurred despite unchanged creatinine clearance. These effects were associated with a significant enhancement in arterial blood pressure in the LP group, but the precise mechanism of these phenomena remains unknown.
dc.description14
dc.description271-82
dc.languageeng
dc.relationJournal Of The Renin-angiotensin-aldosterone System : Jraas
dc.relationJ Renin Angiotensin Aldosterone Syst
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAging
dc.subjectAngiotensin Ii
dc.subjectAnimals
dc.subjectBlood Pressure
dc.subjectCreatinine
dc.subjectDrinking
dc.subjectFemale
dc.subjectHypothalamus
dc.subjectKidney
dc.subjectKidney Function Tests
dc.subjectLithium
dc.subjectMale
dc.subjectOsmolar Concentration
dc.subjectPotassium
dc.subjectPregnancy
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptor, Angiotensin, Type 1
dc.subjectReceptor, Angiotensin, Type 2
dc.subjectSodium
dc.subjectVasopressins
dc.subjectArterial Hypertension
dc.subjectAngiotensin Receptors
dc.subjectCentral Nervous System
dc.subjectKidney Function
dc.subjectLithium Clearance
dc.subjectLow-protein Diet
dc.subjectNatriuresis
dc.subjectRenin-angiotensin System
dc.titleEarly Changes Of Hypothalamic Angiotensin Ii Receptors Expression In Gestational Protein-restricted Offspring: Effect On Water Intake, Blood Pressure And Renal Sodium Handling.
dc.typeArtículos de revistas


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